Results 101 to 110 of about 2,777,990 (323)

Mechanism of Water Inrush Induced by Gob Water Under Repeated Mining and Control Technology Based on Roof Cutting Pressure Relief

Applied Sciences
To mitigate the threat posed by accumulated gob water to underlying coal seams during multi-seam mining, this study investigates the mechanism of water inrush induced by repeated mining and its control through roof cutting pressure relief.
Yongqiang Zhang, Guochuan Zhang, Xiangyu Wang, Dingchao Chen, Xian Wang, Yuan Chu   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Calculation of principal stresses and their directions in selected cutting planes in rock drilling [PDF]

Acta Montanistica Slovaca, 2011
The paper is focused on the analysis of principal stress fields induced in the system of drilling tool-rock during the drilling process in immediate surroundings of their mutual contact. Various load conditions were analyzed, representing torque, loading
František Krepelka, Lucia Ivaničová, Milan Labaš, Jozef Futó   +3 more
doaj  

Correction and accuracy improvement of non-parallel shear zone model

MATEC Web of Conferences, 2018
When applying the non-parallel shear zone model to predict the cutting process parameters of carbon steel workpiece, it is found that there is a big error between the prediction results and the experimental values. And also, the former approach to obtain
Wang Yaoke, Kou Meng, Ding Wei, Ma Huan, Xiong Liangshan   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Metal cutting modelling SPH approach [PDF]

, 2011
The purpose of this work is to evaluate the use of the smoothed particle hydrodynamics (SPH) method within the framework of high speed cutting modelling. First, a 2D SPH based model is carried out using the LS-DYNA® software.
J. Limido, Salaün, Michel, J.L. Lacome, R. Chieragatti, Lacome, Jean-Luc, M. Salaun, Chieragatti, Rémy, Mabru, Catherine, C. Espinosa, Espinosa, Christine, Limido, Jérôme, C. Mabru   +11 more
core   +1 more source

A dual method for polar cuts in disjoint bilinear programming

Croatian Operational Research Review
As one branch of deterministic approaches to disjoint bilinear programming, cutting plane methods are renowned for its ability to systematically reduce the search space by adding cutting planes that are able to cut off regions deemed infeasible or ...
Xiaosong Ding, Jun Ma, Xi Chen, Chao Liu
doaj   +1 more source

Separating valid odd-cycle and odd-set inequalities for the multiple depot vehicle scheduling problem

EURO Journal on Computational Optimization, 2013
We consider the multicommodity network flow formulation of the multiple depot vehicle scheduling problem (MDVSP) and investigate several strategies within a branch-and-cut framework for solving the MDVSP.
Mounira Groiez, Guy Desaulniers, Ahmed Hadjar, Odile Marcotte   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source