Results 101 to 110 of about 23,957 (296)

Cutting Planes for Integer Programs with General Integer Variables [PDF]

, 1995
We investigate the use of cutting planes for integer programs with general integer variables. We show how cutting planes arising from knapsack inequalities can be generated and lifted as in the case of 0-1 variables.
Cécile Cordier, Laurence A. Wolsey, Sebastián Ceria, Hugues Marchand   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A dual method for polar cuts in disjoint bilinear programming

Croatian Operational Research Review
As one branch of deterministic approaches to disjoint bilinear programming, cutting plane methods are renowned for its ability to systematically reduce the search space by adding cutting planes that are able to cut off regions deemed infeasible or ...
Xiaosong Ding, Jun Ma, Xi Chen, Chao Liu
doaj   +1 more source

Separating valid odd-cycle and odd-set inequalities for the multiple depot vehicle scheduling problem

EURO Journal on Computational Optimization, 2013
We consider the multicommodity network flow formulation of the multiple depot vehicle scheduling problem (MDVSP) and investigate several strategies within a branch-and-cut framework for solving the MDVSP.
Mounira Groiez, Guy Desaulniers, Ahmed Hadjar, Odile Marcotte   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Separation algorithms for 0-1 knapsack polytopes [PDF]

, 2010
Valid inequalities for 0-1 knapsack polytopes often prove useful when tackling hard 0-1 Linear Programming problems. To generate such inequalities, one needs separation algorithms for them, i.e., routines for detecting when they are violated.
Letchford, Adam, Kaparis, Konstantinos
core  

Design and verify: A new scheme for generating cutting-planes [PDF]

, 2011
A cutting-plane procedure for integer programming (IP) problems usually involves invoking a black-box procedure (such as the Gomory-Chvátal (GC) procedure) to compute a cutting-plane.
Sebastian Pokutta, Santanu S. Dey
core   +1 more source

Study of the Kinematics, the Working Angles of the Cutters and their Influence on the Gear Cutting Process by Means of the Power Skiving Method

Journal of Mechanical Engineering
The paper deals with the kinematics of the Power Skiving process, the determination of the total cutting speed, the working angles of the cutting wedge of the Power Skiving tool and their influence on the process of cutting gears.
Hrytsay Ihor, Slipchuk Andrii, Borovets Volodymyr   +2 more
doaj   +1 more source

Analysis and stiffness evaluation of a microparallel kinematic machine

Dyna, 2017
This study explores a scaled version of a 3-PRRR parallel configuration that can be used in micro-machining tasks. The study addresses a stiffness model of a micro-parallel kinematic machine (mPKM) by employing an approach involving kinematic and static ...
Ricardo Yáñez-Valdez
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source