Results 91 to 100 of about 23,957 (296)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Permeability prediction of 3D complex fracture networks in deep underground based on fractal analysis of trace maps

Scientific Reports
Estimating the permeability of a three-dimensional (3D) discrete fracture network (DFN) based on its geometric properties can provide a useful alternative to the resource-intensive direct hydraulic computation of the 3D DFN.
Jing Zhang, Liyuan Yu, Qi Ping, Wei Li, Ding Liu   +4 more
doaj   +1 more source

Maximum flows and minimum cuts in the plane [PDF]

Journal of Global Optimization, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mechanism of Water Inrush Induced by Gob Water Under Repeated Mining and Control Technology Based on Roof Cutting Pressure Relief

Applied Sciences
To mitigate the threat posed by accumulated gob water to underlying coal seams during multi-seam mining, this study investigates the mechanism of water inrush induced by repeated mining and its control through roof cutting pressure relief.
Yongqiang Zhang, Guochuan Zhang, Xiangyu Wang, Dingchao Chen, Xian Wang, Yuan Chu   +5 more
doaj   +1 more source

Cutting Plane and Frege Proofs

Information and Computation, 1995
The cutting plane refutation system CP for classical propositional calculus [see \textit{W. Cook}, \textit{C. R. Coullard} and \textit{Gy. Turan}, Discrete Appl. Math. 18, 25-38 (1987; Zbl 0625.90056)], initially coming from works in operation research, can be considered as an extension of resolution based on showing the non-existence of solutions for ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Calculation of principal stresses and their directions in selected cutting planes in rock drilling [PDF]

Acta Montanistica Slovaca, 2011
The paper is focused on the analysis of principal stress fields induced in the system of drilling tool-rock during the drilling process in immediate surroundings of their mutual contact. Various load conditions were analyzed, representing torque, loading
František Krepelka, Lucia Ivaničová, Milan Labaš, Jozef Futó   +3 more
doaj  

Correction and accuracy improvement of non-parallel shear zone model

MATEC Web of Conferences, 2018
When applying the non-parallel shear zone model to predict the cutting process parameters of carbon steel workpiece, it is found that there is a big error between the prediction results and the experimental values. And also, the former approach to obtain
Wang Yaoke, Kou Meng, Ding Wei, Ma Huan, Xiong Liangshan   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source