Results 111 to 120 of about 2,777,990 (323)

Theory and computation of sparse cutting planes

, 2017
Cutting plane plays an important role in the theory and computation of integer programming. Nowadays, most state-of-the-art integer programming solvers tend to bias their cutting plane selection towards sparse ones, which emphasizes the significance of ...
Wang, Qianyi
core   +1 more source

Study of the Kinematics, the Working Angles of the Cutters and their Influence on the Gear Cutting Process by Means of the Power Skiving Method

Journal of Mechanical Engineering
The paper deals with the kinematics of the Power Skiving process, the determination of the total cutting speed, the working angles of the cutting wedge of the Power Skiving tool and their influence on the process of cutting gears.
Hrytsay Ihor, Slipchuk Andrii, Borovets Volodymyr   +2 more
doaj   +1 more source

Analysis and stiffness evaluation of a microparallel kinematic machine

Dyna, 2017
This study explores a scaled version of a 3-PRRR parallel configuration that can be used in micro-machining tasks. The study addresses a stiffness model of a micro-parallel kinematic machine (mPKM) by employing an approach involving kinematic and static ...
Ricardo Yáñez-Valdez
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Possible explanations for different surface quality in laser cutting with 1 micron and 10 microns beams [PDF]

, 2012
In laser　cutting　of　thick　steel　sheets,　quality　difference　is　observed　between　cut　surfaces　obtained　with 1 micron and 10 micron laser beams. This paper investigates physical mechanisms for this interesting and important problem of the wavelength ...
Remy Fabbro, Koji Hirano, FABBRO, Rémy, HIRANO, Koji   +3 more
core   +1 more source

Simulation of Drilling Process for Control of Burr Formation

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
An analytical force model is presented to simulate the cutting force and the chip flow direction in the drilling process. Three dimensional chip flow is interpreted as a piling up of the orthogonal cuttings in the planes containing the cutting velocities
Takashi MATSUMURA, Jürgen LEOPOLD
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Visualized Microstructure Evolution Model Integrating an Analytical Cutting Model with a Cellular Automaton Method during NiTi Smart Alloy Machining

Crystals
In this study, a visualized microstructure evolution model for the primary shear zone during NiTi smart alloy machining was established by integrating an analytical cutting model with a cellular automaton method.
Jiaqi Wang, Ming Li, Qingguang Li, Xianchao Pan, Zixuan Wang, Jing Jia, Renti Liu, Yunguang Zhou, Lianjie Ma, Tianbiao Yu   +9 more
doaj   +1 more source

An Interior Point Method for Solving Semidefinite Programs Using Cutting Planes and Weighted Analytic Centers

Journal of Applied Mathematics, 2012
We investigate solving semidefinite programs (SDPs) with an interior point method called SDP-CUT, which utilizes weighted analytic centers and cutting plane constraints. SDP-CUT iteratively refines the feasible region to achieve the optimal solution. The
John Machacek, Shafiu Jibrin
doaj   +1 more source