Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Archives of Metallurgy and Materials, 2017 This paper presents the influence of cutting parameters (Depth of cut, feed rate, spindle speed and cutting fluid flow rate) on the surface roughness and flank wear of physical vapor deposition (PVD) Cathodic arc evaporation coated TiAlN tungsten carbide
Moganapriya C. +4 more
doaj +1 more source
Study of Residual Stresses and Austenite Gradients in the Surface after Hard Turning as a Function of Flank Wear and Cutting Speed. [PDF]
Materials (Basel), 2023 Mičietová A +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Critical cutting speed for onset of serrated chip flow in high speed machining
, 2014 The transition of continuously smooth chip flow to periodically serrated chip flow as the cutting speed increasing is one of the most fundamental and challenging problems in high speed machining. Here, an explicit expression of the critical cutting speed
Ye GG +4 more
core +1 more source
Study of Cutting Edge Temperature and Cutting Force of End Mill Tool in High Speed Machining
MATEC Web of Conferences, 2017 A wear of cutting tools during machining process is unavoidable due to the presence of frictional forces during removing process of unwanted material of workpiece.
Kiprawi Mohammad Ashaari +4 more
doaj +1 more source
On Coolant Flow Rate-Cutting Speed Trade-Off for Sustainability in Cryogenic Milling of Ti-6Al-4V. [PDF]
Materials (Basel), 2021 Iqbal A +6 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Establishing the Relationship between Cutting Speed and Output Parameters in Belt Grinding on Steels, Aluminum and Nickel Alloys: Development of Recommendations. [PDF]
Materials (Basel), 2021 Syreyshchikova NV +5 more
europepmc +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source