Results 91 to 100 of about 2,039,757 (294)

Effect Of Cutting Speed On The Carbide Cutting Tool In Milling Inconel 718 Alloy

, 2016
Tribology is a phenomenon concerning the relative motion between at least two amalgamating surfaces. In the machining process, surface roughness is the most important element for studying this occurrence, which contributes to the evaluation of part ...
A Ghani, Jaharah, Che Haron, Che Hassan, Abdul Hadi, Musfirah, Kasim, Mohd Shahir   +3 more
core   +1 more source

Onset and evolution of discontinuously segmented chip flow in ultra-high-speed cutting Ti-6Al-4V [PDF]

, 2017
Increasing the cutting speed to an ultra-high level usually gives rise to a chip flow transition from continuously serrated to discontinuously segmented, which is one of the most fundamental and challenging problems in metal cutting.
Ye GG, Xue SF, Dai, LH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China., 戴兰宏, Ma W   +4 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Design and processing test of eel automatic filleting machine

Shipin yu jixie
Objective: A special cutting mechanism for slicing elongated fish with smooth surface was designed. Methods: Taking the slimy eel as the research object, the mechanism of clamping and cutting operation was analyzed.
LIU Mingyong, OUYANG Zhouhuan, HAN Xinguang, XIANG Xue, ZHU Lin   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Simulation of the deflected cutting tool trajectory in complex surface milling [PDF]

, 2011
Since industry is rapidly developing, either locally or globally, manufacturers witness harder challenges due to the growing competitivity. This urges them to better consider the four factors linked to production and output: quality, quantity, cost and
Baili, Maher, Zoubeir Bouaziz, Ali Zghal, Smaoui, Moez, Maher Baili, Zghal, Ali, Dessein, Gilles, Moez Smaoui, Bouaziz, Zoubeir, Gilles Dessein   +9 more
core   +1 more source

Influence of the Heat Treatment Condition upon the High-Speed Cutting Mechanism of Aluminum Alloy A2017

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
This paper discusses the influence of heat treatment condition of aluminum alloy upon cutting mechanism. The orthogonal cutting experiments of A2017-T3 and A2017-O with a cutting speed of from 0.5 m/s to 160 m/s are conducted.
Masato SANDO, Tappei HIGASHI, Jun SHINOZUKA   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Experimental investigation of hydrodynamics of melt layer during laser cutting of steel [PDF]

, 2011
In laser cutting process, understanding of hydrodynamics of melt layer is significant, because it is an important factor which controls the final quality. In this work, we observed hydrodynamics of melt layer on kerf front in the case of laser cutting of
Remy Fabbro, Koji Hirano, FABBRO, Rémy, HIRANO, Koji   +3 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source