Results 71 to 80 of about 2,039,757 (294)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Influence of deposition pressure on structure and properties of AlCrSiN/Mo self-lubricating coating

Cailiao gongcheng
To solve the problem that the cutting temperature rises sharply due to the high friction coefficient of AlCrSiN coated tools during dry cutting， which seriously shortens the service life of the tool， the tribological properties of the coating are ...
WANG Chongyang, LIU Yanmei, LIAN Weifeng, ZHANG Yinhang, HE Meng, XUE Rui, LYU Yuanjiang, LIU Datong, XU Yuanjian, WANG Tiegang   +9 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Monostable Dynamic Analysis of Microbeam-Based Resonators via an Improved One Degree of Freedom Model

Micromachines, 2018
Monostable vibration can eliminate dynamic bifurcation and improve system stability, which is required in many microelectromechanical systems (MEMS) applications, such as microbeam-based and comb-driven resonators.
Lei Li, Qichang Zhang, Wei Wang, Jianxin Han   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Modelling of cutting fibrous composite materials: current practice [PDF]

, 2015
Using fibre reinforced polymers (FRP) is increasing across many industries. Although FRP are laid-up in the near-net shape, several cutting operations are necessary to meet quality and dimensional requirements.
Kahwash, Fadi, Maheri, A., Shyha, Islam, Kahwash, F., Shyha, I., Maheri, Alireza   +5 more
core   +1 more source

Analysis of feed speed and cutting speed of Korean and Japanese combines using a high-speed camera

Tropical Agricultural Research, 2015
Cutting performance of 5 row Daedong industry combines cutting knife and 5 row Kuboda combines cutting blade were experimented using paddy straw as the object. Cutting positions were 68 cm left and right from the centre.
M.H. Lee, B.O. Jin, T.J. Park, C.H. Kim, M. H. Heo, H.T. Kim   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The effect of cutting speed on residual stresses when orthogonal cutting TC4

EPJ Web of Conferences, 2015
As one of the most important parameters in mental cutting, cutting speed has a significant influence on residual stress. Finite element method and experiment method are used to study the relationship between cutting speed and residual stress when ...
Liu Chaofeng, Wang Zengqiang, Zhang Guang, Liu Lei   +3 more
doaj   +1 more source

Effect of cutting speed on the material removal behaviour for sapphire [PDF]

MATEC Web of Conferences
Sapphire optical components are widely used in various industrial sectors. However, they are currently not available through efficient and highly accurate ultra-precision cutting.
Liu Dehui, Li Kejin, Chen Junyun, Qi Yunze   +3 more
doaj   +1 more source