Results 71 to 80 of about 96,665 (264)
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012 This paper discusses the influence of heat treatment condition of aluminum alloy upon cutting mechanism. The orthogonal cutting experiments of A2017-T3 and A2017-O with a cutting speed of from 0.5 m/s to 160 m/s are conducted.
Masato SANDO +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Archives of Metallurgy and Materials, 2017 This paper presents the influence of cutting parameters (Depth of cut, feed rate, spindle speed and cutting fluid flow rate) on the surface roughness and flank wear of physical vapor deposition (PVD) Cathodic arc evaporation coated TiAlN tungsten carbide
Moganapriya C. +4 more
doaj +1 more source
Study of Residual Stresses and Austenite Gradients in the Surface after Hard Turning as a Function of Flank Wear and Cutting Speed. [PDF]
Materials (Basel), 2023 Mičietová A +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Study of Cutting Edge Temperature and Cutting Force of End Mill Tool in High Speed Machining
MATEC Web of Conferences, 2017 A wear of cutting tools during machining process is unavoidable due to the presence of frictional forces during removing process of unwanted material of workpiece.
Kiprawi Mohammad Ashaari +4 more
doaj +1 more source
On Coolant Flow Rate-Cutting Speed Trade-Off for Sustainability in Cryogenic Milling of Ti-6Al-4V. [PDF]
Materials (Basel), 2021 Iqbal A +6 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Advances in Mechanical Engineering, 2015 Minimum quantity lubrication is a technique to have the advantages that cutting fluids bring yet keeping their use at minimum. For the cutting fluids, inedible vegetable oils are potential for minimum quantity lubrication machining.
Mohamed Handawi Saad Elmunafi +2 more
doaj +1 more source