Results 51 to 60 of about 91,053 (267)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Analysis of feed speed and cutting speed of Korean and Japanese combines using a high-speed camera

Tropical Agricultural Research, 2015
Cutting performance of 5 row Daedong industry combines cutting knife and 5 row Kuboda combines cutting blade were experimented using paddy straw as the object. Cutting positions were 68 cm left and right from the centre.
M.H. Lee, B.O. Jin, T.J. Park, C.H. Kim, M. H. Heo, H.T. Kim   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The effect of cutting speed on residual stresses when orthogonal cutting TC4

EPJ Web of Conferences, 2015
As one of the most important parameters in mental cutting, cutting speed has a significant influence on residual stress. Finite element method and experiment method are used to study the relationship between cutting speed and residual stress when ...
Liu Chaofeng, Wang Zengqiang, Zhang Guang, Liu Lei   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effect of metastable retained austenite on dynamic mechanical properties of nanostructured bainitic steel under high-strain rate deformation

Journal of Materials Research and Technology
In this study, modifying the austenitizing temperature offers a strategically viable way towards creating blocky retained austenite (BRA) with varying sizes and morphologies in nanostructured bainitic steel, in strikingly contrast to the conventional ...
Shichao Fan, Ziqing Xu, Hai Hao, Yu Bai, Xiaohu Deng, Dong Guo   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

ABOUT INFLUENCE OF SPEED WORKING BODIES OF DIGGING MACHINES ON THE RESISTANCE FORCE OF SOIL CUTTING

Вестник СибАДИ, 2017
The processes occurring during high-speed cutting of soil is are considered. The dependence of the resistance force of soil cutting from speed of interaction, taking into account the compressibility of soil and the occurrence of wave drag forces is ...
D. S. Semkin
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Turning with shallow cuts at high speeds

Bureau of Standards Journal of Research, 1929
Abstract In this paper a method is described for testing lathe tools under shallow cuts and fine feeds. The relations are determined between the cutting speed, feed, depth of cut, and tool life for carbon and high-speed tool steels. Comparisons are made of tools of different forms and of tool life when cutting dry and with water or lard ...
H. J. French, T. G. Digges
openaire   +1 more source