Surrogate modelling for reliability assessment of cutting tools [PDF]
, 2013 Currently, cutting tool life for machining operations is correlated to process parameters through the widely applied Taylor functions. The latter are valuable expressions in established practice however their generalised nature does not allow accurate ...
Kolios, Athanasios +1 more
core
Cutting performance and wear characteristics of PVD coated and uncoated carbide tools in face milling Inconel 718 aerospace alloy [PDF]
, 2001 In this paper, cutting performance and failure characteristics of two PVD TiN coated and an uncoated tungsten carbide grades with identical geometry are presented.
Jawaid, A., Koksal, S., Sharif, Safian
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Research Progress of Magnetorheological Elastomers and Their Vibration Control Applications
Journal of Harbin University of Science and TechnologyThe magnetorheological elastomer is a magnetic control intelligent material that is prepared by the micron magnetic particles dispersed to the polymer elastomer ，which not only has the excellent mechanical properties of the particle ...
LIU Qiang +4 more
doaj +1 more source
Study on the Engineering Technology of the Structural Design of the Index-able Turning Tool
Journal of Harbin University of Science and Technology, 2017 The optimal geometry of the working part of the cutting tool has an important influence on aspects such as high quality parts processing，improvement of production efficiency and the longer tool life in the cutting process.
HE Geng-huang +4 more
doaj +1 more source
Web-based CBR (case-based reasoning) as a tool with the application to tooling selection [PDF]
, 2005 Over the past few years, manufacturing companies have had to deal with an increasing demand for feature-rich products at low costs. The pressures exerted on their existing manufacturing processes have lead manufacturers to investigate internet-based ...
Aamodt +8 more
core +2 more sources
Single-cell sequencing: A cutting edge tool in molecular medical research
, 2022 Pratibha Misra +2 more
openalex +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Toolpath planning method with constraint of cutting force fluctuation in slow tool servo turning for complex curved surface parts [PDF]
, 2022 Feng-ze Qin +4 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source