Results 41 to 50 of about 3,043 (128)

Disseminated Xanthogranuloma Harboring a GAB2::BRAF Fusion and MITF Pathogenic Variant Successfully Treated With Cobimetinib: A Rare Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Several activating mutations and gene fusions involving the mitogen‐activated protein kinase (MAPK) pathway have appeared in the literature regarding histiocytic neoplasms. We identified a GAB2::BRAF fusion in a cutaneous lesion of a 36‐year‐old male who developed central diabetes insipidus and reddish‐pink grouped papules on the bilateral ...
Pauline C. Xu, Allison M. Cushman‐Vokoun, Christopher R. D’Angelo, Dinesh Pradhan   +3 more
wiley   +1 more source

Genetic testing in paediatric neurological disorders

Developmental Medicine &Child Neurology, EarlyView.
In this study 390 paediatric patients with neurological disorders underwent genetic testing via exome sequencing, commercial panel, in‐house epilepsy, and movement disorder gene panels. Exome sequencing provides the highest diagnostic yield, and severe developmental delay and hypotonia predicted pathogenic variants in the exome sequencing cohort ...
Wafa Bani Uraba, Byoung Chan Lee, Shekeeb S. Mohammad, Katrina Fisk, Michael Buckley, Russell C. Dale, Tony Roscioli, Paediatric Neurogenomic Working Group, Manoj P. Menezes, Sachin Gupta, Christopher Troedson, Esther Tantsis, Richard Webster, Bruce Bennetts, Deepak Gill, Kavitha Kothur   +15 more
wiley   +1 more source

Early sodium‐glucose co‐transporter 2 inhibitor initiation is associated with improved cardiovascular outcomes in type 2 diabetes and acute coronary syndrome

Diabetic Medicine, EarlyView.
Abstract Aims Sodium‐glucose co‐transporter 2 inhibitors have demonstrated cardiovascular benefits in individuals with type 2 diabetes mellitus, but the optimal timing of initiation in those with acute coronary syndrome is not known. This study aims to assess if early therapy at discharge is superior to delayed or no therapy in reduction in major ...
Muhammad Usman Shah, Joanna Kate Ward, Alun Roebuck, Bala Srinivasan, Paul Edward Squires, Claire Elizabeth Hills, Maxime Inghels, Kelvin Lee   +7 more
wiley   +1 more source

Reduced Risk of MASLD and Cardiometabolic Disease Following Renal Denervation Therapy in Patients With Resistant Hypertension

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Autonomic dysfunction increases the risk of cardio‐kidney‐metabolic (CKM) syndrome including metabolic dysfunction‐associated steatotic liver disease (MASLD), type 2 diabetes (T2D), cardiovascular disease (CVD) and chronic kidney disease (CKD).
Alex E. Henney, Matthew Anson, David R. Riley, Laurent Fauchier, Joel P. Giblett, Gregory Y. H. Lip, Rayaz A. Malik, Daniel J. Cuthbertson, Uazman Alam   +8 more
wiley   +1 more source

Diabetic Ketoacidosis: Systematic Review and Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic ketoacidosis (DKA) remains a major cause of diabetes‐related morbidity and mortality worldwide, yet evidence on its management and clinical outcomes across healthcare settings remains limited. We conducted a systematic review and meta‐analysis to evaluate the precipitants, management and outcomes of adult DKA.
Lucy A. Bomphrey, James French, Aspasia Manta, Kalyaani Persad, Katie Scandrett, Ketan Dhatariya, Punith Kempegowda   +6 more
wiley   +1 more source

Generation Rather Than Sex Shapes Wing Morphology in Cydalima perspectalis (Lepidoptera, Crambidae): Insights From Geometric Morphometrics and Climate‐Based Projections

Entomologia Experimentalis et Applicata, EarlyView.
An integrated framework combining geometric morphometrics and ecological niche modeling was applied to Cydalima perspectalis to assess intergenerational morphological variation, test sexual dimorphism, and predict future distribution under climate scenarios. Wing shape effectively discriminated between generations but not between sexes.
Nurver Altun, Cantekin Dursun, Serkan Gül   +2 more
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Periodontitis and Chronic Conditions in Older Adults: A Scoping Review and Evidence Map of Systematic Reviews

Gerodontology, EarlyView.
ABSTRACT Background Periodontitis is a prevalent chronic inflammatory condition that frequently co‐occurs with systemic chronic diseases. Although older adults experience a high burden of both periodontitis and chronic conditions, the extent to which age‐specific evidence has been synthesised remains unclear.
Manisha Tamrakar, Najith Amarasena, Kym Michelle McCormick, Liana Luzzi, Gloria Mejia   +4 more
wiley   +1 more source

Medical emergency response related to MedicAtion InciDents (MERRMAID): a case series and lessons to improve medication safety

Internal Medicine Journal, EarlyView.
Abstract Background Evidence suggests that some medical emergencies in hospital are associated with preventable medication errors or adverse reactions. Aim The purpose of this case series was to investigate and describe the proportion of Medical Emergency Response Team (MERT) activations that are medication‐related, the degree of preventability and ...
Ian Coombes, Amelia Anderson, Fiona Coombes, Gloria Wong, Daisy Lindsay, John Gowardman, Peter Donovan, Sinead Carmichael, Bianca Levkovich, Karen Davies   +9 more
wiley   +1 more source

Age, growth and sexual dimorphism of the monkeyface prickleback (Cebidichthys violaceus)

Journal of Fish Biology, EarlyView.
Abstract Accurate estimates of age, growth and maturation are fundamental to fisheries assessment, conservation and the development of emerging aquaculture species. However, life‐history parameters can vary within species and may be influenced by factors such as sexual dimorphism, which is often poorly quantified in non‐commercial or understudied ...
Kevin D. Hinterman, Matthew R. Hoehn, Luke D. Gardner, Scott L. Hamilton   +3 more
wiley   +1 more source