Results 151 to 160 of about 120,451 (282)

Fermentation Potentials of Baobab Pulp Extract in Soy Yoghurt Production

AgriFood: Journal of Agricultural Products for Food, EarlyView.
The research work was about the importance of sourcing for alternative inoculants to replace the main inoculants regularly used for yoghurt production. The search for baobab pulp extract as replacement yielded result, as soy yoghurt was successfully produced.
Adegbola Oladele Dauda, Nahim Mokolade Adeagbo, Quadri Idowu Akinremi, Taofiqat Damilola Maiyaki, Adedamola Israel Abioye, Zulfiqoh Tolani AbdulAkeem, Damilare Johnson Folaranmi   +6 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Complete Recovery Following Intentional Potassium Cyanide Poisoning Despite Delayed Hydroxocobalamin Administration: A Case Report. [PDF]

Cureus
Lichtarska K, Łydka M, Bajek W, Falana J, Lewandowska J, Machała I, Libudzic N, Łaciak J, Granatowski P.   +8 more
europepmc   +1 more source

Redox‐Neutral Vicinal Dialkylation of Aryl Boronic Esters via the Palladium/Norbornene Cooperative Catalysis

Angewandte Chemie, EarlyView.
A new mode of the palladium/norbornene (Pd/NBE) cooperative catalysis, that is, redox‐neutral difunctionalization of aryl boronic esters with two electrophiles, has been developed, which can be used to streamline the preparation of a functionalized benzoazepane.
Rong Ye, Peimiao He, Liyan Kan, Thomas R. Plambeck, Guangbin Dong   +4 more
wiley   +2 more sources

Towards Sustainable Bioleaching of Platinum Group Metals from Spent Automotive Catalysts. [PDF]

Materials (Basel)
Kuralay Y, Ilkhani Z, Hardy J, Capozzi L, Aiouache F.   +4 more
europepmc   +1 more source

Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation

Angewandte Chemie, EarlyView.
The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam, Josep M. Luis, Arnau Call, Quentin Lefebvre, Matthew S. Sigman, Miquel Costas   +5 more
wiley   +2 more sources

A de‐novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly‐Controlled Kinetic Electron Transfer Gating

Angewandte Chemie, EarlyView.
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha, Rajesh Kancherla, Jorge Escorihuela, Shana Chandran, Mrinal K. Bera, Magnus Rueping, Burkhard König   +6 more
wiley   +2 more sources

Hydrogen Cyanide Generation by Pseudomonas aeruginosa Blunts the Host Innate Immune Response. [PDF]

J Infect Dis
Szabo C, Santos SS, Findlay J, Bremer O, Petrosino M, Philipp TM, Kierońska-Rudek A, Zuhra K, Boss GR, Nordmann P.   +9 more
europepmc   +1 more source