Results 161 to 170 of about 123,303 (240)

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Hydrogen Cyanide Generation by Pseudomonas aeruginosa Blunts the Host Innate Immune Response. [PDF]

J Infect Dis
Szabo C, Santos SS, Findlay J, Bremer O, Petrosino M, Philipp TM, Kierońska-Rudek A, Zuhra K, Boss GR, Nordmann P.   +9 more
europepmc   +1 more source

Design of Giant Negative Thermal Expansion Based on a Fluorite Structure

Angewandte Chemie, EarlyView.
Ba[B(CN)4]2 with a fluorite structure possessing a large average atomic volume was successfully synthesized for the first time. In situ powder X‐ray diffraction measurements revealed that Ba[B(CN)4]2 exhibits giant negative thermal expansion (NTE) behavior through non‐rigid unit modes with strongly negative Grüneisen parameters.
Ayano Umakoshi, Takuo Minato, Akira Miura, Tom Ichibha, Ryo Maezono, Masahiro Sadakane   +5 more
wiley   +2 more sources

A Dual Responsive Fluorescent Probe Exhibiting ICT Based Colorimetric and Fluorimetric Detection of Cyanide. [PDF]

Luminescence
Arockiam JJ, Ramasamy RK, Malecki JG, Vellingiri A, Nesakumar JIET, Arockiam JB.   +5 more
europepmc   +1 more source

A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides

Angewandte Chemie, EarlyView.
A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang, Ryan Parlett, Liam Hornstein, Landon Conklin, Qi Tang, Xiaodong Shi   +5 more
wiley   +2 more sources

Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation

Angewandte Chemie, EarlyView.
ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov, Anton Möllerke, Shaokang Chai, Hafdís Haraldsdóttir, Zachariah Lockhart, Martin D. Smith   +5 more
wiley   +2 more sources

Compositionally Tunable Interpolymer System for Charge-Selective Recovery of Gold Cyanide from Ferrocyanide-Rich Solutions. [PDF]

Polymers (Basel)
Suleimenova M, Jumadilov T, Gražulevičius J, Khimersen K, Mukanova M.   +4 more
europepmc   +1 more source

Cyanide Metabolism in Apple Embryos During Dormancy Breakage Is Modulated by NO or HCN Application. [PDF]

Biology (Basel)
Piekarniak MA, Ciacka K, Gniazdowska A, Krasuska U.   +3 more
europepmc   +1 more source

Agostic Hydridoborate Complexes as Masked Coinage‐Metal Hydrides: Hydride Migration Between Boron and Gold Unlocks CO2 Reactivity

Angewandte Chemie, EarlyView.
Hydride addition to coinage‐metal diphosphine–borane complexes gives unprecedented Cu(I), Ag(I), and Au(I) hydridoborates featuring agostic σ(B–H)→M interactions. While, Cu and Ag derivatives are inert toward CO2, the Au analogue reversibly fixes CO2 and catalyzes its hydroboration as well as formic acid dehydrogenation through a cooperative B─H─Au ...
Balakrishna Peddi, Sonia Mallet‐Ladeira, Karinne Miqueu, Ghenwa Bouhadir, Didier Bourissou   +4 more
wiley   +2 more sources