Results 241 to 250 of about 39,245 (323)

Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease

Annals of Neurology, EarlyView.
Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias, Siiri Sarv, Nathalie Bonello‐Palot, Laura Carrera‐García, Carlos Ortez, Jesica Expósito‐Escudero, Delia Yubero, Jordi Muchart, Emilien Delmont, Eve Õiglane‐Shlik, Teele Meren, Sanna Puusepp, Ülle Murumets, Gajja S. Salomons, Bjarne Udd, Liis Väli, Lara Cantarero, Carsten G. Bönnemann, Andrés Nascimento, Santiago Ramón‐Maiques, Katrin Õunap, Janet Hoenicka, Daniel Natera‐de Benito, Francesc Palau   +23 more
wiley   +1 more source

Enantioselective Rhodium‐Catalyzed Cycloisomerization of 1,5‐Bis(allenes) to Access 1,2‐cis‐Ethynyl‐ and Vinyl‐Substituted Five‐Membered (Hetero)Cycles

Angewandte Chemie, EarlyView.
The enantioselective Rh‐catalyzed cycloisomerization of 1,5‐bis(allenes) is reported for the preparation of 1,2‐cis‐ethynyl‐ and vinyl‐substituted (hetero)cyclic products in high yields and with excellent diastereo‐ and enantioselectivities. This method leads to the preparation of a valuable chiral building block in organic synthesis including ...
Farhad Panahi, Marzieh Samadani, Felix Bauer, Bernhard Breit   +3 more
wiley   +2 more sources

Comprehensive review of clinical presentation, treatment, and prognostic factors of airway burns. [PDF]

J Med Life
Giurgiu RA, Bordeanu-Diaconescu EM, Grosu-Bularda A, Frunza A, Grama S, Dumitru CŞ, Costache RA, Cristescu CI, Lascar I, Hariga CS.   +9 more
europepmc   +1 more source

Planning for Cyanide Emergencies [PDF]

AAOHN Journal, 2008
openaire   +3 more sources

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source

Iridium‐Catalyzed Reductive Deoxygenation of Esters for the Synthesis of Sterically Hindered Ethers

Angewandte Chemie, EarlyView.
A general method for accessing sterically hindered ethers via reductive deoxygenation of readily prepared ester starting materials is reported. Employing commercially available and bench‐stable IrCl(CO)(P[OCH(CF3)2]3)2 (1–2 mol%) and tetramethyldisiloxane (TMDS) as reductant, this single‐vessel approach operates under mild conditions and provides a ...
Yaseen A. Almehmadi, Anna J. Passmore, Pablo Gabriel, Darren J. Dixon   +3 more
wiley   +2 more sources

Cyanide and Cyanogenic Compounds-Toxicity, Molecular Targets, and Therapeutic Agents. [PDF]

Biomolecules
Lachowicz JI, Alexander J, Aaseth JO.
europepmc   +1 more source

Electrochemical Deoxygenative Silylation of Alcohols

Angewandte Chemie, EarlyView.
Herein, electroreductive deoxysilylation of benzylic and allylic alcohols is demonstrated. The cathodic transformation proceeds via carbanionic intermediates and can be extended to aldehydes and ketones. Mechanistic studies reveal that the reaction outcome is dependent on the thermodynamics and kinetics for the coupling step in combination with the ...
Piret Villo, Malin Lill, Ziwei Fan, Kevin Breitwieser, Jai White, Sergio Pérez Morente, Mårten Ahlquist, Helena Lundberg   +7 more
wiley   +2 more sources

Temperature and Light Regimes Shape Seasonal Variation in Glucosinolate Hydrolysis in Red Cabbage. [PDF]

J Agric Food Chem
Púčiková V, Kluge SI, Witzel K, Rohn S, Hanschen FS.   +4 more
europepmc   +1 more source

Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions

Angewandte Chemie, EarlyView.
Several processes are reported that enable the rapid diversification of bridged nucleoside analogues (NAs) starting from a common and readily prepared fluorohydrin. Also, several clinically relevant bridged nucleosides are now prepared in as few as three synthetic steps, creating new opportunities for examining structure‐activity relationships within ...
Cohan Huxley, Ethan Fung, Bara Singh, Guillermo Caballero‐García, Garrett Muir, Steven M. Silverman, Louis‐Charles Campeau, Robert Britton   +7 more
wiley   +2 more sources