Results 271 to 280 of about 38,937 (354)

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Metathetical Exchange, Synthesis, and Carbon Dioxide Addition of Higher Homologues of Group 9 Metal Carbynes

open access: yesAngewandte Chemie International Edition, EarlyView.
A one‐pot synthesis for previously unknown heavy carbynes of Group 9 metals is presented. Furthermore, in a hitherto unknown metathetical exchange reaction, the transition metal plumbylidynes were converted into the respective stannylidynes in reaction with terphenyl stannylene chloride, and the germylidynes were formed from the corresponding ...
Lennart G. Holzapfel   +5 more
wiley   +1 more source

NITROPRUSSIDE AND CYANIDE

open access: yesBritish Journal of Anaesthesia, 1975
Cole Pv, Vesey Cj
openaire   +3 more sources

Is Phenylnitrene a Missing Link in the Formation of Polycyclic Aromatic Nitrogen Heterocycles?

open access: yesAngewandte Chemie International Edition, EarlyView.
A new formation pathway for polycyclic aromatic nitrogen heterocycles (PANHs) has been found. The reaction of phenylnitrene and the propargyl radical leads to quinoline, proving that nitrenes are suitable precursors for nitrogen incorporation mechanisms.
Rahel Arns   +6 more
wiley   +1 more source

closo‐Carboranyl Analogs of β‐Arylethylamines: Direct Synthesis from Alkenes via EnT‐Catalysis

open access: yesAngewandte Chemie International Edition, EarlyView.
A strategy to directly synthesize closo‐carboranyl analogs of medicinal chemically important β‐arylethylamines from alkenes is reported. This reaction is enabled by the first formation of closo‐carboranyl radicals by energy transfer (EnT) catalysis and its unique mechanistic features.
Fritz Paulus   +8 more
wiley   +1 more source

Reductive sulfinylation by nucleophilic chain isomerization of sulfonylpyridinium. [PDF]

open access: yesNat Commun
Li Y   +6 more
europepmc   +1 more source

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