Results 1 to 10 of about 256,906 (340)

The diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus [PDF]

Gut Pathogens
Vibrio vulnificus is a marine pathogen that is a significant cause of foodborne infections, leading to chronic diseases and primary septicemia. Wound infections caused by this bacterium can result in serious complications such as ulceration and tissue ...
Jhih-Ren Yang, Kai-Ting Chen, Yi-Wen Chen, Shu-Jung Lai   +3 more
doaj   +2 more sources

Introduction of the Carotenoid Biosynthesis α-Branch Into Synechocystis sp. PCC 6803 for Lutein Production

Frontiers in Plant Science, 2021
Lutein, made by the α-branch of the methyl-erythritol phosphate (MEP) pathway, is one of the most abundant xanthophylls in plants. It is involved in the structural stabilization of light-harvesting complexes, transfer of excitation energy to chlorophylls
Martin Lehmann, Evgenia Vamvaka, Alejandro Torrado, Peter Jahns, Marcel Dann, Lea Rosenhammer, Amel Aziba, Dario Leister, Thilo Rühle   +8 more
doaj   +1 more source

Functional Characterization of Three Diterpene Synthases Responsible for Tetracyclic Diterpene Biosynthesis in Scoparia dulcis

Plants, 2022
Scoparia dulcis produces unique biologically active diterpenoids such as scopadulcic acid B (SDB). They are biosynthesized from geranylgeranyl diphosphate (GGPP) via syn-copalyl diphosphate (syn-CPP) and scopadulanol as an important key intermediate.
Jung-Bum Lee, Tomoya Ohmura, Yoshimi Yamamura   +2 more
doaj   +1 more source

Damage Signaling by Extracellular Nucleotides: A Role for Cyclic Nucleotides in Elevating Cytosolic Free Calcium?

Frontiers in Plant Science, 2021
Extracellular ATP (eATP) is now held to be a constitutive damage-associated molecular pattern (DAMP) that is released by wounding, herbivory or pathogen attack.
Jian Sun, Jian Sun, Youzheng Ning, Limin Wang, Katie A. Wilkins, Julia M. Davies   +5 more
doaj   +1 more source

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Molecules, 2021
Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing ...
Joanna M. Watt, Richard Graeff, Barry V. L. Potter   +2 more
doaj   +1 more source

Cyclic nucleotide signalling in malaria parasites [PDF]

Open Biology, 2017
The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types.
David A. Baker, Laura G. Drought, Christian Flueck, Stephanie D. Nofal, Avnish Patel, Maria Penzo, Eloise M. Walker   +6 more
doaj   +1 more source

Comparative Genomic Analysis of Ochratoxin A Biosynthetic Cluster in Producing Fungi: New Evidence of a Cyclase Gene Involvement

Frontiers in Microbiology, 2020
The widespread use of Next-Generation Sequencing has opened a new era in the study of biological systems by significantly increasing the catalog of fungal genomes sequences and identifying gene clusters for known secondary metabolites as well as novel ...
Massimo Ferrara, Antonia Gallo, Giancarlo Perrone, Donato Magistà, Scott E. Baker, Scott E. Baker   +5 more
doaj   +1 more source

Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression

Frontiers in Pharmacology, 2022
The relationship between depression, its etiology and therapy, and the cAMP signaling system have been studies for decades. This review will focus on cAMP, G proteins and adenylyl cyclase and depression or antidepressant action.
Jeffrey M. Schappi, Jeffrey M. Schappi, Mark M. Rasenick, Mark M. Rasenick, Mark M. Rasenick, Mark M. Rasenick   +5 more
doaj   +1 more source

Novel Modular Rhodopsins from Green Algae Hold Great Potential for Cellular Optogenetic Modulation Across the Biological Model Systems

Life, 2020
Light-gated ion channel and ion pump rhodopsins are widely used as optogenetic tools and these can control the electrically excitable cells as (1) they are a single-component system i.e., their light sensing and ion-conducting functions are encoded by ...
Mayanka Awasthi, Kumari Sushmita, Manish Singh Kaushik, Peeyush Ranjan, Suneel Kateriya   +4 more
doaj   +1 more source

Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC

Respiratory Research, 2022
Background Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate cyclase ...
Eva M. Becker-Pelster, Michael G. Hahn, Martina Delbeck, Lisa Dietz, Jörg Hüser, Johannes Kopf, Thomas Kraemer, Tobias Marquardt, Thomas Mondritzki, Johannes Nagelschmitz, Sylvia M. Nikkho, Philippe V. Pires, Hanna Tinel, Gerrit Weimann, Frank Wunder, Peter Sandner, Joachim Schuhmacher, Johannes-Peter Stasch, Hubert K. F. Truebel   +18 more
doaj   +1 more source