Results 91 to 100 of about 300,632 (358)

Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high‐dose insulin therapy

British Journal of Clinical Pharmacology, EarlyView.
Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Betty S. H. Chan, Katherine Z. Isoardi, Darren M. Roberts, Ong Sook Har   +3 more
wiley   +1 more source

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources

Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

PLoS ONE, 2012
Cyclic diguanosine monophosphate (c-di-GMP) and cyclic diadenosine monophosphate (c-di-AMP) are recently identified signaling molecules. c-di-GMP has been shown to play important roles in bacterial pathogenesis, whereas information about c-di-AMP remains
Yinlan Bai, Jun Yang, Xin Zhou, Xinxin Ding, L. Eisele, G. Bai   +5 more
semanticscholar   +1 more source

Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization, and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms [PDF]

, 2016
Aim: Skeletal muscle nitric oxide–cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity.
Balke, Jordan E, Brouckaert, Peter, Buys, Emmanuel S, Knowels, Gary, Madorma, Derik, Marcinek, David J, Moon, Younghye, Percival, Justin M, Siegel, Michael P   +8 more
core   +1 more source

Structural basis of activity and allosteric control of diguanylate cyclase.

Proceedings of the National Academy of Sciences of the United States of America, 2004
Recent discoveries suggest that a novel second messenger, bis-(3'-->5')-cyclic di-GMP (c-diGMP), is extensively used by bacteria to control multicellular behavior.
Carmen Chan, Ralf Paul, D. Samoray, Nicolas Amiot, B. Giese, U. Jenal, Tilman Schirmer   +6 more
semanticscholar   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Are β3‐adrenoceptor gene polymorphisms relevant for urology?

Neurourology and Urodynamics, Volume 42, Issue 1, Page 33-39, January 2023., 2023
Abstract Aims β3‐adrenoceptors (ARs) are an important drug target for the treatment of overactive bladder syndrome (OAB) and are under investigation for other indications. The human β3‐AR gene is polymorphic; an exchange of amino acid tryptophan (Trp) for arginine (Arg) in position 64 of the receptor protein is the most frequent and best‐studied ...
Martin C. Michel
wiley   +1 more source

Regulation of nitric oxide signaling by formation of a distal receptor-ligand complex. [PDF]

, 2017
The binding of nitric oxide (NO) to the heme cofactor of heme-nitric oxide/oxygen binding (H-NOX) proteins can lead to the dissociation of the heme-ligating histidine residue and yield a five-coordinate nitrosyl complex, an important step for NO ...
Britt, R David, Guo, Yirui, Herzik, Mark A, Iavarone, Anthony T, Marletta, Michael A, Suess, Daniel LM   +5 more
core   +1 more source

Inhibition of signaling downstream of beta‐2 adrenoceptor by propranolol in prostate cancer cells

The Prostate, Volume 83, Issue 3, Page 237-245, February 15, 2023., 2023
Abstract Background There is accumulating evidence that propranolol, an antagonist of beta‐1 and beta‐2 adrenoreceptors, extends survival of patients with prostate cancer; yet it is not known whether propranolol inhibits beta‐adrenergic signaling in prostate cancer cells, or systemic effects of propranolol play the leading role in slowing down cancer ...
Aljoharah Alaskar, Amaal Abdulraqeb Ali, Sazzad Hassan, Zakia Shinwari, Ayodele Alaiya, Urs von Holzen, Lance Miller, George Kulik   +7 more
wiley   +1 more source

Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines [PDF]

, 2019
Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme constituted by two subunits, α1 and β1. Previously we have shown that 17β-estradiol (E2) exerts opposite effects on these subunits by increasing α1 and decreasing both β1 expression and enzymatic ...
Bollani, Sabrina Natalia, Cabilla, Jimena Paula, Cordeiro, Georgina, Duvilanski, Beatriz Haydee, Pino, María Teresa Luján, Ricci, Analía Gabriela, Ronchetti, Sonia Alejandra   +6 more
core   +1 more source