Results 101 to 110 of about 300,632 (358)

Ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicology of the subfamily Gomphrenoideae (Amaranthaceae): A comprehensive review

Chemistry &Biodiversity, Accepted Article.
The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves, Giulia Cristina Andreoli de Souza, Alvaro Jose Hernandez Tasco, Marcos Jose Salvador   +3 more
wiley   +1 more source

Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation. [PDF]

, 2017
ObjectivesIncreased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways.
Gao, Mei Hua, Giamouridis, Dimosthenis, Guo, Tracy, Hammond, H Kirk, Kim, Young Chul, Lai, N Chin   +5 more
core   +2 more sources

Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Mammals have nine differentially regulated isoforms of G protein-responsive transmembrane-spanning adenylyl cyclases. We now describe the existence of a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or ...
J. Buck, Meeghan L. Sinclair, Lissy Schapal, M. Cann, L. Levin   +4 more
semanticscholar   +1 more source

Studies on Guanylate Cyclase

Journal of Biological Chemistry, 1974
Abstract A new rapid and reliable assay for guanylate cyclase was established, which employs a simple procedure to isolate guanosine 3' : 5'-monophosphate with neutral aluminum oxide and Dowex 1 formate columns. Using this assay guanylate cyclase was purified about 30-fold from rat brain soluble fraction by ammonium sulfate fractionation, followed by ...
Kinya Nakazawa, Mamoru Sano
openaire   +3 more sources

Characterization of the Cubamyces Menziesii Terpenome

ChemBioChem, EarlyView.
The genome of Cubamyces menziesii reveals 18 putative sesquiterpene cyclase genes. These genes are cloned and expressed in Escherichia coli, yielding 10 active enzymes. Using farnesyl diphosphate as substrate, the enzymes are analyzed, and the products characterized after bioconversion, uncovering diverse sesquiterpene structures. This study highlights
Létitia Leydet, Julie Couillaud, Agnès Amouric, Elise Courvoisier‐Dezord, Carole Avesque, Thierry Giardina, Mireille Attolini, Pierre Rousselot‐Pailley, Katia Duquesne, Marie‐Noelle Rosso, Gilles Iacazio   +10 more
wiley   +1 more source

Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

FASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022
Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas, Arfaxad Reyes‐Alcaraz, Kehe Ruan, Bradley K. McConnell, Richard A. Bond   +4 more
wiley   +1 more source

PACAP induces FSHβ gene expression via EPAC. [PDF]

, 2019
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core  

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway.

Journal of Biological Chemistry, 2000
Differential modes for beta(1)- and beta(2)-adrenergic receptor (AR) regulation of adenylyl cyclase in cardiomyocytes is most consistent with spatial regulation in microdomains of the plasma membrane.
V. Rybin, Xiaohong Xu, M. Lisanti, S. Steinberg   +3 more
semanticscholar   +1 more source

Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense

ChemBioChem, EarlyView.
Lienhwalides are novel tropolone–maleidride hybrid molecules unique in nature. Absolute configuration is solved by semisynthetic approaches and X‐ray analysis. Interplay between both lwt and lwm biosynthetic gene clusters is responsible for the production of lienhwalides.
Katharina Schmidt, Esteban Charria‐Girón, Tatiana E. Gorelik, Christian Kleeberg, Jackson M. Muema, Simone Heitkämper, Bart Verwaaijen, Eric Kuhnert, Jennifer Gerke, Jörn Kalinowski, Kevin D. Hyde, Marc Stadler, Russell Cox, Frank Surup   +13 more
wiley   +1 more source