Results 111 to 120 of about 300,632 (358)
Recoverin Regulates Light-dependent Phosphodiesterase Activity in Retinal Rods [PDF]
, 2004 The Ca2+-binding protein recoverin may regulate visual transduction in retinal rods and cones, but its functional role and mechanism of action remain controversial.
Baylor, D. A. +6 more
core +5 more sources
Designing Enzymatic Reactivity with an Expanded Palette
ChemBioChem, EarlyView.Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley +1 more source
Newly identified NO-sensor guanylyl cyclase/connexin 43 association is involved in cardiac electrical function [PDF]
, 2017 Background: Guanylyl cyclase, a heme-containing alpha 1 beta 1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO-GC1-cGMP pathway negatively regulates cardiomyocyte contractility and protects against cardiac ...
Beuve, Annie +7 more
core +2 more sources
Clade III Synthases Add Cyclic And Linear Terpenoids To The Psilocybe Metabolome
ChemBioChem, Accepted Article.Psilocybe “magic mushrooms” are best known for their indolethylamine psilocybin, yet they encode enzymes for a much more diverse arsenal of small and potentially bioactive molecules. Here, we report on four Psilocybe cubensis clade III sesquiterpene synthases, CubB‐CubE, whose genes are differently expressed in fruiting bodies compared to vegetative ...
Nick Zschoche +7 more
wiley +1 more source
Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
ChemistryEurope, EarlyView.This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley +1 more source
Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity [PDF]
, 2016 Evidence from human studies and transgenic mice lacking the type 3 adenylyl cyclase (AC3) indicates that AC3 plays a role in the regulation of body weight. It is unknown in which brain region AC3 exerts such an effect.
Cao, Hong +3 more
core +2 more sources
Myocardial adenyl cyclase: activation by thyroid hormones and evidence for two adenyl cyclase systems [PDF]
, 1969 Gerald S. Levey, Stephen E. Epstein
openalex +1 more source
Journal of Biological Chemistry, 1974 Abstract Adenylate cyclase from the rat renal medulla has been solubilized with the nonionic detergents Triton X-100 and Lubrol PX. The enzyme activity in a 100,000 x g Lubrol PX supernatant is resolved into three peaks by gel filtration on Sepharose 4B: Peak A in the void volume; Peak B, the major form, with a Stokes radius of 64 A; and Peak C with a ...
openaire +3 more sources
Chemistry – A European Journal, EarlyView.Highly water‐soluble Npy‐sulfenate functions as an efficient oxidizing agent for the formation of disulfide bonds in thiol‐containing peptides. The Npy‐sulfenate can be used to form a disulfide bond with a thiol‐containing peptide produced by thiol‐additive‐free NCL, thereby facilitating the one‐pot synthesis of adrenomedullin.
Akihiro Taguchi +8 more
wiley +1 more source
Decreased myocardial adenyl cyclase activity in hypothyroidism [PDF]
, 1969 Gerald S. Levey +2 more
openalex +1 more source