Results 151 to 160 of about 244,573 (357)
Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs [PDF]
, 1974 Yvonne C. Clement‐Cormier +3 more
openalex +1 more source
PACAP induces FSHβ gene expression via EPAC. [PDF]
, 2019 Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core
European Journal of Heart Failure, EarlyView.Mode of death stratified by implantable cardioverter‐defibrillator (ICD) status. CI, confidence interval; CV, cardiovascular; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio; SCD, sudden cardiac death. Abstract Aims Guidelines recommend the use of implantable cardioverter‐defibrillators (ICDs) to reduce the risk
Pishoy Gouda +11 more
wiley +1 more source
Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application
Exploration, EarlyView.This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang +4 more
wiley +1 more source
Exploration, EarlyView.Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu +5 more
wiley +1 more source
Food Frontiers, EarlyView.EPL relieves depressive‐like behaviors by upregulating hippocampal PACAP via Rb3/Rc synergy, showing dual modulation of synaptic plasticity and neuroinflammation. ABSTRACT Panax notoginseng Leaf (PNL), an edible‐medicinal botanical resource, shows potential as functional ingredients for alleviating depression, owing to their unique saponin composition.
Shu‐zhen Ran +7 more
wiley +1 more source
The activity of glucagon-stimulated adenylate cyclase from rat liver plasma membranes is modulated by the fluidity of its lipid environment [PDF]
, 1978 Irene Dipple, Miles D. Houslay
openalex +1 more source
Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia
Glia, EarlyView.Adrenergic signaling through ADRB2 modulates phagocytosis in microglia. Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia. ADRB2 activation inhibits both P2Y6 function and gene expression. ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their environment ...
Thomas Deluc +10 more
wiley +1 more source
Glucose Inhibition of Adenylate Cyclase in Intact Cells of Escherichia coli B [PDF]
, 1974 Alan Peterkofsky, Celia Gazdar
openalex +1 more source