Results 161 to 170 of about 244,573 (357)

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang   +7 more
wiley   +1 more source

A Soluble 2,3-Oxidosqualene Sterol Cyclase

open access: hybrid, 1967
P.D.G. Dean   +3 more
openalex   +1 more source

scRiskCell: A single‐cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes

open access: yesiMeta, EarlyView.
scRiskCell is an interpretable intelligent computational framework that leverages nearly 500,000 islet cell expression profiles from 106 donors across different continuous disease states. By calculating the intrinsic relationship between donor disease states and cell expression profiles, it assigns a pseudo‐cell state index to each cell.
Xueqin Xie   +7 more
wiley   +1 more source

Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review

open access: yesJournal of General and Family Medicine, EarlyView.
Abstract Objectives This narrative review identifies pitfalls in managing constipation in older adults and provides evidence‐based recommendations to avoid them. Methods A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in ...
Madunil Niriella   +3 more
wiley   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

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