Aging Cell, EarlyView.Aged rats and human are more susceptible to MASLD‐related liver injury, steatosis, and fibrosis, accompanied by worsening of endothelial dysfunction. The SIRT1/p‐eNOS/NO pathway is involved in aggravated MASLD caused by aging‐related LSECs dysfunction.
Qingqing Dai +5 more
wiley +1 more source
Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in <i>Dictyostelium</i>. [PDF]
CellsJaiswal P, Kimmel AR.
europepmc +1 more source
Aging Cell, EarlyView.Physical activity promotes functional improvements in both robust and physically frail older adults, driven by distinct adaptation mechanisms in the mitochondria‐inflammation axis that are influenced by age and frailty status. ABSTRACT Physical exercise has been associated with healthier aging trajectories, potentially preventing or mitigating age ...
Fiona Limanaqi +11 more
wiley +1 more source
Molecular mechanisms of resistance to tyrosine kinase inhibitor in clear cell renal cell carcinoma
International Journal of Urology, Volume 29, Issue 12, Page 1419-1428, December 2022., 2022 Abstract Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC). Loss of von Hippel–Lindau tumor suppressor gene is frequently observed in ccRCC and increases the expression of hypoxia‐inducible factors and their targets, including epidermal growth factor, vascular endothelial growth factor, and platelet ...
Yohei Sekino +3 more
wiley +1 more source
Xanthomonas citri subsp. citri requires a polyketide cyclase to activate the type III secretion system for virulence. [PDF]
BMC MicrobiolZhu S, Wu S, Liu Y, Zhang Z, Zou H.
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The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver
, 1971 Stephen L. Pohl +4 more
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Potential of alternative control of leaf‐cutting ants using essential oils: A systematic review
Agricultural and Forest Entomology, EarlyView.Abstract Leaf‐cutting ants (LCAs) are abundant and cause considerable damage to agricultural and forest crops in the Neotropical region and are commonly controlled using sulfluramid‐based ant baits. However, this active ingredient is a precursor of perfluorooctane sulfonic acid (PFOS), a persistent, human‐made pollutant that poses serious environmental
Heloisa S. S. Pinheiro +9 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5743-5754, December 2022., 2022 Abstract Vascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Yvette N. Hlophe, Anna M. Joubert
wiley +1 more source
Emerging antihypertensive therapies and cardiovascular, kidney, and metabolic outcomes: a Mendelian randomization study. [PDF]
Eur Heart J Cardiovasc PharmacotherLe NN +4 more
europepmc +1 more source
Soluble adenylate cyclase from the culture medium of Bordetella pertussis: purification and characterization [PDF]
, 1976 Erik L. Hewlett, J. Wolff
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