Results 11 to 20 of about 244,573 (357)
Squalene cyclase and oxidosqualene cyclase from a fern [PDF]
FEBS Letters, 2007 Ferns are the most primitive vascular plants. The phytosterols of ferns are the same as those of higher plants, but they produce characteristic triterpenes. The most distinct feature is the lack of oxygen functionality at C‐3, suggesting that the triterpenes of ferns may be biosynthesized by direct cyclization of squalene.
Yutaka Ebizuka +3 more
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A Symphony of Cyclases: Specificity in Diguanylate Cyclase Signaling [PDF]
Annual Review of Microbiology, 2017 Cyclic diguanylate (c-di-GMP) is a near universal signaling molecule produced by diguanylate cyclases that can direct a variety of bacterial behaviors. A major area of research over the last several years has been aimed at understanding how a cell with dozens of diguanylate cyclases can deploy a given subset of them to produce a desired phenotypic ...
Kurt M. Dahlstrom, George A. O'Toole
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Life, 2020 Light-gated ion channel and ion pump rhodopsins are widely used as optogenetic tools and these can control the electrically excitable cells as (1) they are a single-component system i.e., their light sensing and ion-conducting functions are encoded by ...
Mayanka Awasthi +4 more
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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC
Respiratory Research, 2022 Background Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate cyclase ...
Eva M. Becker-Pelster +18 more
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Frontiers in Pharmacology, 2023 Soluble guanylate cyclase agonists and guanylate cyclase C agonists are two popular drugs for diseases of the cardiovascular system and digestive systems. The common denominator in these conditions is the potential therapeutic target of guanylate cyclase.
Qinan Yin +15 more
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Aerobic Barley Mg-protoporphyrin IX Monomethyl Ester Cyclase is Powered by Electrons from Ferredoxin
Plants, 2020 Chlorophyll is the light-harvesting molecule central to the process of photosynthesis. Chlorophyll is synthesized through 15 enzymatic steps. Most of the reactions have been characterized using recombinant proteins.
David Stuart +6 more
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Nucleotidyl cyclase activity of recombinant soluble guanylyl cyclase [PDF]
BMC Pharmacology, 2009 The ubiquitously expressed soluble guanylyl cyclase(sGC) converts guanosine 5'-triphosphate (GTP) to gua-nosine 3':5'-cyclic monophosphate (cGMP). The het-erodimeric protein is activated by nitric oxide (NO). sGCplays a key role in the regulation of vascular tone and neu-rotransmission.
Volkhard Kaever +3 more
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Structural basis of retinal membrane guanylate cyclase regulation by GCAP1 and RD3
Frontiers in Molecular Neuroscience, 2022 Retinal membrane guanylate cyclases (RetGC1 and RetGC2) are expressed in photoreceptor rod and cone cells, where they promote the onset of visual recovery during phototransduction.
James B. Ames
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PLoS ONE, 2021 We investigated circulatory dynamics in patients with vasodepressor type neurally mediated syncope (VT-NMS) by performing high-resolution Holter electrocardiography and a correlation analysis of changes in adenylate cyclase activity, blood pressure, and ...
Misaki Hasegawa +13 more
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Adenylate Cyclase and Guanylate Cyclase in Myxococcus xanthus [PDF]
Microbiology, 1984 Myxococcus xanthus M300 vegetative cells contained significant amounts of adenylate and guanylate cyclase activity. The latter was distributed between the 100000 g supernatant and pellet fractions, required divalent cations for activity and exhibited an apparent Km of 1 mm.
A. L. Devi, H. D. McCURDY
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