Results 201 to 210 of about 244,573 (357)

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, EarlyView.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

Genome-Wide Analysis of Oxidosqualene Cyclase Genes in <i>Artemisia annua</i>: Evolution, Expression, and Potential Roles in Triterpenoid Biosynthesis. [PDF]

Curr Issues Mol Biol
Guo C, Xu S, Guo X.
europepmc   +1 more source

A Temperature-Sensitive Change in the Energy of Activation of Hormone-Stimulated Hepatic Adenylyl Cyclase

, 1973
Peter Kreiner, James J. Keirns, Mark W. Bitensky   +2 more
openalex   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, EarlyView.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

Distribution of a Fatty Acid Cyclase Enzyme System in Plants [PDF]

, 1979
Brady A. Vick, Dunja Zimmermann
openalex   +1 more source

The value of CD47 and CAP1 levels in early diagnosis and MACE prediction for patients with non-ST-segment elevation myocardial infarction. [PDF]

BMC Cardiovasc Disord
Li M, Jin D, Xie C, Cui X, Cong H, Hu Y.
europepmc   +1 more source

Clinical and Biochemical Characterization of Specific GUCY2D Alleles Associated With a Rare Form of Night Blindness. [PDF]

Invest Ophthalmol Vis Sci
Ba-Abbad R, Peshenko IV, Daich Varela M, Lin S, Arno G, Mahroo OA, Egan C, Robson AG, Olshevskaya EV, Dizhoor AM, Webster AR.   +10 more
europepmc   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice. [PDF]

Immunohorizons
Yahagi A, Iseki M, Yaku K, Nakagawa T, Itoh M, Mukai T, Ishihara K.   +6 more
europepmc   +1 more source

Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

British Journal of Pharmacology, EarlyView.
Background and Purpose The pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk, Merle F. Sternschulte, Oliver Soehnlein, Marcel Bermudez, Carsten A. Raabe, Ursula Rescher   +5 more
wiley   +1 more source