Results 221 to 230 of about 256,906 (340)

Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High‐Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader‐Blinded Study

open access: yesNeurogastroenterology &Motility, EarlyView.
Our study showed that, in healthy controls, acute administration of linaclotide increased the total number of long‐distance propagating and the pre‐prandial pancolonic pressurizations. Further studies need to address whether the observed effects are directly or indirectly mediated by the mechanism of action of this useful medication to treat chronic ...
Christian Lambiase   +7 more
wiley   +1 more source

Soluble guanylate cyclase induces cranial vasodilation and headache in adults: a randomized trial. [PDF]

open access: yesBrain Commun
Rasmussen NB   +7 more
europepmc   +1 more source

Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis

open access: green, 2009
Yossan‐Var Tan   +8 more
openalex   +1 more source

Role of solubile guanylyl cyclase 11 (SGC11) isoform in mice corpus cavernosum smooth muscle relaxation [PDF]

open access: yes, 2007
Brouckaert, Peter   +4 more
core  

Decoding plant defense signaling using the defenseless mutant

open access: yesNew Phytologist, EarlyView.
Summary Can plants live without defenses? Mutant analysis in Arabidopsis thaliana has identified numerous regulators of biotic, abiotic, and hormone‐based defenses, but the redundancy among separate defense pathways remains unexplored. We constructed an Arabidopsis mutant, defenseless, lacking six canonical defense pathways using abi1‐1 (abscisic acid),
Bikash Baral, Mikael Brosché
wiley   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

open access: yesAnnals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg   +4 more
wiley   +1 more source

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