Results 261 to 270 of about 300,632 (358)

The Vasopressin-sensitive Adenylate Cyclase of the Rat Kidney

, 1974
Rabary M. Rajerison, Jeannine Marchetti, Christian Roy, Joël Bockaert, Serge Jard   +4 more
openalex   +1 more source

Soluble Guanylate Cyclase Stimulator, BAY41-8543: A Promising Approach for the Treatment of Chronic Heart Failure Caused by Pressure and Volume Overload. [PDF]

Pharmacol Res Perspect
Martišková A, Sýkora M, Andelová N, Ferko M, Gawrys O, Andelová K, Kala P, Červenka L, Szeiffová Bačová B.   +8 more
europepmc   +1 more source

New insights into the putative role of leucine-rich repeat proteins of Leptospira interrogans and their participation in host cell invasion: an in silico analysis. [PDF]

Front Cell Infect Microbiol
Foltran BB, Gaspar JP, Silva IRM, Pires HM, Andrade FB, Costa GM, Paixao JEL, Fernandes LGV, Teixeira AF, Nascimento ALTO.   +9 more
europepmc   +1 more source

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera

The FEBS Journal, EarlyView.
Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin, Aoife Giblin, Aleksandra Judina, Punchita Rujirachaivej, Laura G. Corral, Eliza Glennon, Zhi Xian Tai, Tian Feng, Eduardo Torres, Alina Zorn, Julia Gorelik, Elka Kyurkchieva, Pa Thai Yenchitsomanus, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie   +16 more
wiley   +1 more source

Correction for Matsuzaki et al., Transcriptional drift in aging cells: A global decontroller. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae. [PDF]

Cardiovasc Res
Fu J, Mansfield C, Diakonov I, Judina A, Delahaye M, Bhogal N, Sanchez-Alonso JL, Kamp T, Gorelik J.   +8 more
europepmc   +1 more source

The requirement of guanine nucleotides for glucagon stimulation of adenylate cyclase in rat liver plasma membranes.

, 1977
Narimichi Kimura, N NAGATA
openalex   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Begomovirus capsid proteins interact with cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase of its whitefly vector and modulate virus retention within its vector. [PDF]

J Virol
Ghosh S, Mondal B, Jassar O, Ghanim M, Gautam S, Reddy Netla V, Srinivasan R.   +6 more
europepmc   +1 more source

A PDE4 shortform degrader: a first in isoform‐specific PDE4 inhibition

The FEBS Journal, EarlyView.
Clinically used phosphodiesterase 4 (PDE4) inhibitors lack selectivity for PDE4 enzyme isoforms, which leads to documented side effects. Building in enzyme selectivity has proved difficult because all PDE4 enzymes share highly conserved catalytic domains. The report by Sin et al.
Donald H. Maurice
wiley   +1 more source