Results 271 to 280 of about 300,632 (358)

Editorial: Addictions and eating behavior. [PDF]

Front Nutr
Sotomayor-Zárate R.
europepmc   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Serum miR-329-3p as a potential biomarker for poor ovarian response in an in vitro fertilization. [PDF]

Clin Exp Reprod Med
Kim JH, Kim HO, Lee SY, Park EA, Choi KH, Kang K, Yu EJ, Koong MK, Lee KA.   +8 more
europepmc   +1 more source

Measuring catalytic mechanism similarity – a new approach to study enzyme function and evolution

The FEBS Journal, EarlyView.
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Antonio J. M. Ribeiro, Ioannis G. Riziotis, Neera Borkakoti, Pedro A. Fernandes, Maria J. Ramos, Janet M. Thornton   +5 more
wiley   +1 more source

Intracellular cAMP signaling-induced Ca²⁺ influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts. [PDF]

Pflugers Arch
Kimura M, Nomura S, Ouchi T, Kurashima R, Nakano R, Sekiya H, Kuroda H, Kono K, Shibukawa Y.   +8 more
europepmc   +1 more source

Adenylate cyclase 9 expression level is associated with hormone receptor-positive breast cancer and predicts patient prognosis. [PDF]

Nagoya J Med Sci
Sugino K, Shibata M, Adachi Y, Soeda I, Ichikawa T, Inaishi T, Kanaya E, Kanda M, Hayashi M, Masuda N.   +9 more
europepmc   +1 more source

Development and pharmacological characterization of novel multi‐ calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating peptide receptor antagonists

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Debbie L. Hay, Christopher S. Walker   +5 more
wiley   +1 more source

SGLT‐2 inhibitors for cardiac amyloidosis: Hype or hope?

European Journal of Clinical Investigation, EarlyView.
Flavio Tangianu, Eleonora Nicolini, Francesco Dentali, Aldo Bonaventura   +3 more
wiley   +1 more source

CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide. [PDF]

Life (Basel)
Nagy-Grócz G, Spekker E, Körtési T, Laborc KF, Bohár Z, Fejes-Szabó A, Vécsei L, Párdutz Á.   +7 more
europepmc   +1 more source