Targeting prostate cancer with site-specific antibody-drug conjugates enabled by tandemly fused ADP-ribosyl cyclases. [PDF]
Zhang L+15 more
europepmc +1 more source
The pharmacotherapeutic potential of neuropeptide Y for chronic pain
Abstract Chronic pain is a major medical problem that requires new therapeutic options. Discovered by Victor Mutt in 1982, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief. Genetic knockdown of NPY or pharmacological inhibition of its receptors demonstrates that NPY signaling tonically inhibits indices of chronic ...
Al A. Nie, Bradley K. Taylor
wiley +1 more source
Inhibition of Contractility of Isolated Caprine Detrusor by the Rho Kinase Inhibitor Fasudil and Reversal by the Guanylyl Cyclase Inhibitor ODQ. [PDF]
Jeeviha NJ+6 more
europepmc +1 more source
Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review
Untargeted salivary proteomics identified promising biological molecules consistently over‐ or under‐expressed in periodontitis patients compared to periodontally healthy subjects, but further targeted approaches are required for their validation. ABSTRACT Aim Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases ...
Matteo Corana+7 more
wiley +1 more source
Carotenoid metabolomic and transcriptomic analyses provide insights into the flower color transition in Lonicera macranthoides. [PDF]
Lv LL, Li LY, Pi JH.
europepmc +1 more source
The Vasopressin-sensitive Adenylate Cyclase of the Rat Kidney
Rabary M. Rajerison+4 more
openalex +1 more source
ABSTRACT Although mass, synchronised spawning of scleractinian corals is a well‐known phenomenon, its underlying molecular mechanisms, especially those that achieve synchronous release of gametes, are still unknown. In the genus Acropora, the dominant scleractinian coral in shallow reefs, spawning timing is synchronised in any given location, but often
Yuki Yoshioka+7 more
wiley +1 more source
Development and pharmacological characterization of novel multi- calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide receptor antagonists. [PDF]
Tasma Z+5 more
europepmc +1 more source