Results 291 to 300 of about 300,632 (358)
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Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
Nature Medicine, 2008Stephan Schilling +2 more
exaly +2 more sources
Glutaminyl Cyclase, Diseases, and Development of Glutaminyl Cyclase Inhibitors
Journal of Medicinal Chemistry, 2021Pyroglutamate (pE) modification, catalyzed mainly by glutaminyl cyclase (QC), is prevalent throughout nature and is particularly important in mammals including humans for the maturation of hormones, peptides, and proteins. In humans, the upregulation of QC is involved in multiple diseases and conditions including Alzheimer's disease, Huntington's ...
Chenshu Xu, Yi-nan Wang, Haiqiang Wu
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Activation of guanyl cyclase and adenyl cyclase by secretin
Biochimica et Biophysica Acta (BBA) - Enzymology, 1973Abstract Properties of rat liver guanyl cyclase and adenyl cyclase and the effects of hormones on the activity of these enzymes have been investigated. 1. 1. Secretin ( 2·10 −7 –60·10 −7 M ) stimulates guanyl cyclase activity of 18 000 × g supernantants of rat liver homogenates with no change in the Michaelis-Menten constant
Sally A. Little +2 more
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International Journal of Oral Surgery, 1978
Certain hormones regulate the activity of their target cells by stimulating adenyl cyclase, which is an enzyme located within the target cell's plasma membrane. Adenyl cyclase catalyzes the formation of cyclic AMP, which is released into the cell and modulates cell functions. In this communication the characteristics of adenyl cyclase are reviewed. The
D, Coppe, M L, Steer
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Certain hormones regulate the activity of their target cells by stimulating adenyl cyclase, which is an enzyme located within the target cell's plasma membrane. Adenyl cyclase catalyzes the formation of cyclic AMP, which is released into the cell and modulates cell functions. In this communication the characteristics of adenyl cyclase are reviewed. The
D, Coppe, M L, Steer
openaire +2 more sources
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.
Physiological Reviews, 2008The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ...
F. Malavasi +7 more
semanticscholar +1 more source
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.
Science, 2000Spermatozoa undergo a poorly understood activation process induced by bicarbonate and mediated by cyclic adenosine 3',5'-monophosphate (cAMP). It has been assumed that bicarbonate mediates its effects through changes in intracellular pH or membrane ...
Yanqiu Chen +6 more
semanticscholar +1 more source
Structure and regulation of soluble guanylate cyclase.
Annual Review of Biochemistry, 2012Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it functions as the primary activator of soluble guanylate cyclase (sGC).
E. Derbyshire, M. Marletta
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Conversion of a Guanylyl Cyclase to an Adenylyl Cyclase
Methods, 1999Guanylyl cyclases catalyze the formation of cGMP from GTP, but display extensive identity at the catalytic domain primary amino acid level with the adenylyl cyclases. The recent solving of the crystal structures of soluble forms of adenylyl cyclase has resulted in predictions of those amino acids important for substrate specificity.
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Guanylate Cyclase Activating Proteins, Guanylate Cyclase and Disease
2002A range of cone and cone-rod dystrophies (CORD) have been observed in man, caused by mutations in retinal guanylate cyclase 1 (RetGC1) and guanylate cyclase activating protein 1 (GCAP 1). The CORD causing mutations in RetGC1 are located at a mutation "hot spot" within the dimerisation domain, where R838 is the key residue.
Annette M. Payne +5 more
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