Cyclase - Open Access .click

Journal of Medicinal Chemistry, 2021
Pyroglutamate (pE) modification, catalyzed mainly by glutaminyl cyclase (QC), is prevalent throughout nature and is particularly important in mammals including humans for the maturation of hormones, peptides, and proteins. In humans, the upregulation of QC is involved in multiple diseases and conditions including Alzheimer's disease, Huntington's ...
Chenshu Xu, Yi-nan Wang, Haiqiang Wu
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Activation of guanyl cyclase and adenyl cyclase by secretin

Biochimica et Biophysica Acta (BBA) - Enzymology, 1973
Abstract Properties of rat liver guanyl cyclase and adenyl cyclase and the effects of hormones on the activity of these enzymes have been investigated. 1. 1. Secretin ( 2·10 −7 –60·10 −7 M ) stimulates guanyl cyclase activity of 18 000 × g supernantants of rat liver homogenates with no change in the Michaelis-Menten constant
Sally A. Little, W.J. Thompson, Robert H. Williams +2 more
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Adenyl cyclase

International Journal of Oral Surgery, 1978
Certain hormones regulate the activity of their target cells by stimulating adenyl cyclase, which is an enzyme located within the target cell's plasma membrane. Adenyl cyclase catalyzes the formation of cyclic AMP, which is released into the cell and modulates cell functions. In this communication the characteristics of adenyl cyclase are reviewed. The
D, Coppe, M L, Steer
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Conversion of a Guanylyl Cyclase to an Adenylyl Cyclase

Methods, 1999
Guanylyl cyclases catalyze the formation of cGMP from GTP, but display extensive identity at the catalytic domain primary amino acid level with the adenylyl cyclases. The recent solving of the crystal structures of soluble forms of adenylyl cyclase has resulted in predictions of those amino acids important for substrate specificity.
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chemistry
biochemistry
biology

enzyme
medicine
adenylate kinase

internal medicine
endocrinology
receptor