Results 301 to 310 of about 256,906 (340)
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International Journal of Oral Surgery, 1978
Certain hormones regulate the activity of their target cells by stimulating adenyl cyclase, which is an enzyme located within the target cell's plasma membrane. Adenyl cyclase catalyzes the formation of cyclic AMP, which is released into the cell and modulates cell functions. In this communication the characteristics of adenyl cyclase are reviewed. The
D, Coppe, M L, Steer
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Certain hormones regulate the activity of their target cells by stimulating adenyl cyclase, which is an enzyme located within the target cell's plasma membrane. Adenyl cyclase catalyzes the formation of cyclic AMP, which is released into the cell and modulates cell functions. In this communication the characteristics of adenyl cyclase are reviewed. The
D, Coppe, M L, Steer
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Glutaminyl Cyclase, Diseases, and Development of Glutaminyl Cyclase Inhibitors
Journal of Medicinal Chemistry, 2021Pyroglutamate (pE) modification, catalyzed mainly by glutaminyl cyclase (QC), is prevalent throughout nature and is particularly important in mammals including humans for the maturation of hormones, peptides, and proteins. In humans, the upregulation of QC is involved in multiple diseases and conditions including Alzheimer's disease, Huntington's ...
Chenshu Xu, Yi-nan Wang, Haiqiang Wu
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Journal of Receptors and Signal Transduction, 2008
Adenylate cyclase (AC) (ATP diphosphate-lyase cyclizing; EC 4.6.1.1) is a key component of the adenylate cyclase signaling system and catalyzes the generation of cyclic adenosine monophosphate (cAMP) from ATP. This review summarizes data from the literature and the authors' laboratory on the investigation of plant transmembrane (tmAC) and soluble (sAC)
Lidiya A, Lomovatskaya +2 more
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Adenylate cyclase (AC) (ATP diphosphate-lyase cyclizing; EC 4.6.1.1) is a key component of the adenylate cyclase signaling system and catalyzes the generation of cyclic adenosine monophosphate (cAMP) from ATP. This review summarizes data from the literature and the authors' laboratory on the investigation of plant transmembrane (tmAC) and soluble (sAC)
Lidiya A, Lomovatskaya +2 more
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1993
Publisher Summary This chapter describes the enzyme (adenylyl cyclase) that effect the synthesis of Adenosine 3’,5’-cyclic monophosphate (cAMP) in various bacterial species. The content will rather reflect current major interests. The adenylyl cyclase from Escherichia coli has been a major subject of research interest ever since it was identified as ...
A, Peterkofsky +5 more
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Publisher Summary This chapter describes the enzyme (adenylyl cyclase) that effect the synthesis of Adenosine 3’,5’-cyclic monophosphate (cAMP) in various bacterial species. The content will rather reflect current major interests. The adenylyl cyclase from Escherichia coli has been a major subject of research interest ever since it was identified as ...
A, Peterkofsky +5 more
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Guanylate Cyclase Activating Proteins, Guanylate Cyclase and Disease
2002A range of cone and cone-rod dystrophies (CORD) have been observed in man, caused by mutations in retinal guanylate cyclase 1 (RetGC1) and guanylate cyclase activating protein 1 (GCAP 1). The CORD causing mutations in RetGC1 are located at a mutation "hot spot" within the dimerisation domain, where R838 is the key residue.
Richard J, Newbold +5 more
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Natural Product Reports, 2016
This review summarises the characterised bacterial terpene cyclases and their products and discusses the enzyme mechanisms.
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This review summarises the characterised bacterial terpene cyclases and their products and discusses the enzyme mechanisms.
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Activation of guanyl cyclase and adenyl cyclase by secretin
Biochimica et Biophysica Acta (BBA) - Enzymology, 1973Abstract Properties of rat liver guanyl cyclase and adenyl cyclase and the effects of hormones on the activity of these enzymes have been investigated. 1. 1. Secretin ( 2·10 −7 –60·10 −7 M ) stimulates guanyl cyclase activity of 18 000 × g supernantants of rat liver homogenates with no change in the Michaelis-Menten constant
W J, Thompson +2 more
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American Journal of Respiratory Cell and Molecular Biology, 1999
Signal transduction via receptors that couple to guanine nucleotide binding proteins (G proteins) is pervasive throughout eukaryotic and prokaryotic biology. In humans, there are thought to be thousands of different G protein–coupled receptors (GPCRs), which carry out an amazingly diverse array of signaling, such as odorant detection, phototransduction,
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Signal transduction via receptors that couple to guanine nucleotide binding proteins (G proteins) is pervasive throughout eukaryotic and prokaryotic biology. In humans, there are thought to be thousands of different G protein–coupled receptors (GPCRs), which carry out an amazingly diverse array of signaling, such as odorant detection, phototransduction,
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Current Opinion in Structural Biology, 2006
Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep ...
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Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep ...
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Journal of the American Chemical Society, 2011
This study demonstrates that a tetraprenyl-β-curcumene cyclase, which was originally identified as a sesquarterpene cyclase that converts a head-to-tail type of monocycle to a pentacycle, also cyclizes a tail-to-tail type of linear squalene into a bicyclic triterpenol, 8α-hydroxypolypoda-13,17,21-triene. The 8α-hydroxypolypoda-13,17,21-triene was found
Tsutomu, Sato +4 more
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This study demonstrates that a tetraprenyl-β-curcumene cyclase, which was originally identified as a sesquarterpene cyclase that converts a head-to-tail type of monocycle to a pentacycle, also cyclizes a tail-to-tail type of linear squalene into a bicyclic triterpenol, 8α-hydroxypolypoda-13,17,21-triene. The 8α-hydroxypolypoda-13,17,21-triene was found
Tsutomu, Sato +4 more
openaire +2 more sources