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Guanylate Cyclase Activating Proteins, Guanylate Cyclase and Disease
2002A range of cone and cone-rod dystrophies (CORD) have been observed in man, caused by mutations in retinal guanylate cyclase 1 (RetGC1) and guanylate cyclase activating protein 1 (GCAP 1). The CORD causing mutations in RetGC1 are located at a mutation "hot spot" within the dimerisation domain, where R838 is the key residue.
Annette M. Payne +5 more
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Journal of Receptors and Signal Transduction, 2008
Adenylate cyclase (AC) (ATP diphosphate-lyase cyclizing; EC 4.6.1.1) is a key component of the adenylate cyclase signaling system and catalyzes the generation of cyclic adenosine monophosphate (cAMP) from ATP. This review summarizes data from the literature and the authors' laboratory on the investigation of plant transmembrane (tmAC) and soluble (sAC)
Nadejda V. Filinova +2 more
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Adenylate cyclase (AC) (ATP diphosphate-lyase cyclizing; EC 4.6.1.1) is a key component of the adenylate cyclase signaling system and catalyzes the generation of cyclic adenosine monophosphate (cAMP) from ATP. This review summarizes data from the literature and the authors' laboratory on the investigation of plant transmembrane (tmAC) and soluble (sAC)
Nadejda V. Filinova +2 more
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The Guanylyl Cyclase Receptors
Methods, 1999In the early 1980s both our group (Hansbrough & Garbers, 1981; Garberset al., 1982) and that of Norio Suzuki (Suzukiet al., 1981) identified the active material in sea urchin egg conditioned media that could stimulate sperm motility and metabolism. In the sea urchinsHemicentrotus pulcherrimusorStrongylocentrotus purpuratus, the active material was ...
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Molecular and Cellular Biochemistry, 1991
Hormone-sensitive adenylyl cyclase is a model system for the study of receptor-mediated signal transduction. It is comprised of three types of components: 1) receptors for hormones that regulate cyclic AMP (cAMP) synthesis, 2) regulatory GTP binding proteins (G proteins), and 3) the family of enzymes, the adenylyl cyclases.
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Hormone-sensitive adenylyl cyclase is a model system for the study of receptor-mediated signal transduction. It is comprised of three types of components: 1) receptors for hormones that regulate cyclic AMP (cAMP) synthesis, 2) regulatory GTP binding proteins (G proteins), and 3) the family of enzymes, the adenylyl cyclases.
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Critical Reviews in Microbiology, 2004
Cyclic AMP is a ubiquitous messenger that integrates many processes of the cell. Diverse families of adenylate cyclases and phosphodiesterases stringently regulate the intracellular concentration of cAMP. Any alteration in the cytosolic concentration of cAMP has a profound effect on the various processes of the cell.
Praveen Kumar +2 more
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Cyclic AMP is a ubiquitous messenger that integrates many processes of the cell. Diverse families of adenylate cyclases and phosphodiesterases stringently regulate the intracellular concentration of cAMP. Any alteration in the cytosolic concentration of cAMP has a profound effect on the various processes of the cell.
Praveen Kumar +2 more
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Adenylate cyclase and guanylate cyclase of normal and denervated skeletal muscle [PDF]
Neurology, 1977 Cyclic nucleotides mediate the intracellular effects of various extracellular influences. To explore the possibility that nerve-muscle influences are mediated by cyclic nucleotides, we studied the effect of denervation on the cyclase enzymes of rabbit gastrocnemius using the contralateral, unoperated limb as the control.
Charles Lewinstein, Steven Novom
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Analytical Biochemistry, 1967
Abstract A method for measuring adenyl cyclase in “membrane” fraction of animal tissues has been developed. The assay measures the conversion of 14 C-adenosine 5′-triphosphate to 14 C-adenosine 3′,5′-monophosphate. The incubation is carried out at 30°C in the presence of caffeine, magnesium, phosphoenolpyruvic acid, pyruvate kinase, Tris buffer ...
William J. Reddy +3 more
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Abstract A method for measuring adenyl cyclase in “membrane” fraction of animal tissues has been developed. The assay measures the conversion of 14 C-adenosine 5′-triphosphate to 14 C-adenosine 3′,5′-monophosphate. The incubation is carried out at 30°C in the presence of caffeine, magnesium, phosphoenolpyruvic acid, pyruvate kinase, Tris buffer ...
William J. Reddy +3 more
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Assay of glutaminylpeptide cyclase
1989Publisher Summary This chapter describes a simple assay for glutaminyl peptide cyclase applicable to a number of different tissues. The enzymes found in porcine pituitary are perhaps the best characterized. It is a glycoprotein exhibiting charge and size heterogeneity and is predominantly found in secretory vesicles. It also has a neutral pH optimum,
Jeanne B. Koger +2 more
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Histochemistry of Adenylate Cyclase
1984Publisher Summary This chapter reviews the methodical problems hampering an adequate localization of adenylate cyclase and discusses the merits and disadvantages of different methods currently available. The chapter presents evidence in support of the validity of model systems for the simulation of certain in situ conditions.
H. Luppa +3 more
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Natural Product Reports, 2016
This review summarises the characterised bacterial terpene cyclases and their products and discusses the enzyme mechanisms.
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This review summarises the characterised bacterial terpene cyclases and their products and discusses the enzyme mechanisms.
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