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GUANYLYL CYCLASE-LINKED RECEPTORS
Pharmacology & Therapeutics, 1991The guanylyl cyclase receptor family contains members that exist in both the particulate and soluble fractions of cell homogenates. Based on cloning studies, proteins with guanylyl cyclase activity contain a single transmembrane domain, or exist as heterodimers with no apparent transmembrane domains.
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The Guanylyl Cyclase Receptors
Methods, 1999In the early 1980s both our group (Hansbrough & Garbers, 1981; Garberset al., 1982) and that of Norio Suzuki (Suzukiet al., 1981) identified the active material in sea urchin egg conditioned media that could stimulate sperm motility and metabolism. In the sea urchinsHemicentrotus pulcherrimusorStrongylocentrotus purpuratus, the active material was ...
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Conversion of a Guanylyl Cyclase to an Adenylyl Cyclase
Methods, 1999Guanylyl cyclases catalyze the formation of cGMP from GTP, but display extensive identity at the catalytic domain primary amino acid level with the adenylyl cyclases. The recent solving of the crystal structures of soluble forms of adenylyl cyclase has resulted in predictions of those amino acids important for substrate specificity.
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European Journal of Biochemistry, 1970
An enzyme system catalyzing the formation of guanosine cyclic 3′:5′‐monophosphate (Guo‐3′:5′‐P) from GTP has been found in various tissues of the rat including kidney, spleen, liver, brain, heart, skeletal muscle and adipose tissue. The highest guanyl cyclase activity was measured in the lung.
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An enzyme system catalyzing the formation of guanosine cyclic 3′:5′‐monophosphate (Guo‐3′:5′‐P) from GTP has been found in various tissues of the rat including kidney, spleen, liver, brain, heart, skeletal muscle and adipose tissue. The highest guanyl cyclase activity was measured in the lung.
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From adenylate cyclase to guanylate cyclase
Journal of Molecular Biology, 1992Annie Beuve, Antoine Danchin
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