Results 31 to 40 of about 300,632 (358)

Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease.

Circulation, 2011
Soluble guanylate cyclase (sGC), a key enzyme of the nitric oxide (NO) signaling pathway, is attracting rapidly growing interest as a therapeutic target in cardiopulmonary disease, with several sGC agonists currently in clinical development.
J. Stasch, P. Pacher, Oleg V. Evgenov
semanticscholar   +1 more source

cAMP activates adenylate and guanylate cyclase of Dictyostelium discoideum cells by binding to different classes of cell-surface receptors. A study with extracellular Ca2+ [PDF]

, 1985
cAMP induces a transient increase of cAMP and cGMP levels in Dictyostelium discoideum cells. Fast binding experiments reveal three types of cAMP-binding site (S, H and L), which have different off-rates (t0.5, 0.7-15 s) and different affinities (Kd, 15 ...
Brachet, Bumann, De Wit, Devreotes, Dinauer, Gerisch, Gerisch, Janssens, Juliani, Kay, Konijn, Leichtling, Marin, Mato, Pannbacker, Roos, Schaap, Shaffer, Stadel, Toews, Van Haastert, Van Haastert, Van Haastert, Van Haastert, Van Haastert, Van Haastert   +25 more
core   +3 more sources

Modulation of sensory information processing by a neuroglobin in C. elegans [PDF]

, 2016
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. We show that in the C. elegans URX O2 sensing neurons two putative molecular O2 sensors, a neuroglobin and O2-binding soluble guanylate cyclases, work antagonistically to sculpt a slowly ...
arxiv   +1 more source

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma. [PDF]

, 2018
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in ...
Akerman, Simon, Baca, Serapio M, Waschek, James A   +2 more
core   +2 more sources

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources

Functional activity of peptide ion channels in tethered bilayer lipid membranes: Review

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Ion transport across biomembranes plays a major role in living cells. This fundamental function is normally carried out by molecules with both a hydrophobic and a hydrophilic side (amphiphilic molecules), which aggregate within the membrane forming a hydrophilic pore (the ion channel) permitting the selective translocation of permeant ions ...
Rolando Guidelli, Lucia Becucci
wiley   +1 more source

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. [PDF]

, 2017
INTRODUCTION: Colorectal cancer remains the second leading cause of cancer death in the United States, and new strategies to prevent, detect, and treat the disease are needed.
Aka, Allison A., Pattison, Amanda M., Rappaport, Jeff A., Sato, Takami, Snook, Adam E., Waldman, Scott A.   +5 more
core   +2 more sources

NO activation of guanylyl cyclase [PDF]

The EMBO Journal, 2004
Nitric oxide (NO)-sensitive guanylyl-cyclase (GC) is the most important receptor for the signaling molecule NO. Activation of the enzyme is brought about by binding of NO to the prosthetic heme group. By monitoring NO-binding and catalytic activity simultaneously, we show that NO activates GC only if the reaction products of the enzyme are present.
Michael Russwurm, Doris Koesling
openaire   +3 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Applying synthetic biology strategies to bioelectrochemical systems

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Although the past 20 years have seen significant advances in tailoring materials for improving the performance of bioelectrochemical systems, recently, there have been efforts in utilizing the synthetic biology toolkit for engineering organisms for bioelectrochemical systems.
Fangyuan Dong, Olja Simoska, Erin Gaffney, Shelley D. Minteer   +3 more
wiley   +1 more source