Results 81 to 90 of about 300,632 (358)

Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements [PDF]

, 2011
Neurons of the Grueneberg ganglion (GG) in the anterior nasal region of mouse pups respond to cool temperatures and to a small set of odorants. While the thermosensory reactivity appears to be mediated by elements of a cyclic guanosine monophosphate ...
Berghard A, Biel M, Biron D, Brechbühl J, Breer H, Chao YC, Duda T, Fleischer J, Fleischer J, Fleischer J, Fleischer J, Fleischer J, Fuss SH, Grosmaitre X, Grota LJ, Guo D, Halem HA, Halpern M, Heinz Breer, Hu J, Jia C, Joerg Fleischer, Katharina Mamasuew, Kimoto H, Kimoto H, Koos DS, Krieger J, Kuhara A, Kuhn M, Leinders-Zufall T, Lin H, Liu CY, Ma M, Mamasuew K, Mamasuew K, Mamasuew K, Martin Biel, Matsuoka M, Munger SD, Munger SD, Nina Hofmann, Norlin EM, Roppolo D, Ruey-Bing Yang, Schmid A, Storan MJ, Sun L, Verena Kretzschmann   +47 more
core   +2 more sources

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

Proceedings of the National Academy of Sciences of the United States of America, 1994
Estrogenic hormones, believed to exert most of their effects via the direct interaction of their receptors with chromatin, are found to increase cAMP in target breast cancer and uterine cells in culture and in the intact uterus in vivo.
S. Aronica, W. Kraus, B. Katzenellenbogen   +2 more
semanticscholar   +1 more source

Adenylyl Cyclases in Mycobacteria [PDF]

Journal of Life Science, 2011
Adenylyl cyclase (AC) catalyzes the formation of cyclic AMP (cAMP) from ATP. The cAMP produced by AC serves as a secondary messenger in a variety of signal transduction pathways, and controls various cellular functions in many organisms. ACs can be grouped into six classes based on their primary amino acid sequences. Eukaryotes and mycobacteria contain
Han-Seung Jeon, Jeong-Il Oh, In-Jeong Ko
openaire   +2 more sources

Pathways-driven Sparse Regression Identifies Pathways and Genes Associated with High-density Lipoprotein Cholesterol in Two Asian Cohorts [PDF]

arXiv, 2013
Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. In a second step, important single nucleotide
arxiv  

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. [PDF]

, 2019
Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-
Hammel, Michal, Horst, Benjamin G, Hurley, James H, Marletta, Michael A, Morris, Kyle L, Rosenberg, Daniel J, Yokom, Adam L   +6 more
core  

Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]

, 2012
Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao, Storm, Daniel R., Xia, Zhengui   +2 more
core   +2 more sources

Conserved Chloroplast Open-reading Frame ycf54 Is Required for Activity of the Magnesium Protoporphyrin Monomethylester Oxidative Cyclase in Synechocystis PCC 6803

Journal of Biological Chemistry, 2012
Background: The cyclase step in chlorophyll biosynthesis remains uncharacterized. Results: Ycf54 forms a complex with other oxidative cyclase components, and a ycf54 mutant accumulates the cyclase substrate.
S. Hollingshead, Jana Kopečná, P. J. Jackson, D. P. Canniffe, Paul A. Davison, M. Dickman, R. Sobotka, C. Hunter   +7 more
semanticscholar   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Accepted Article.
Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe Bornscheuer   +4 more
wiley   +1 more source

Role of guanylyl cyclase modulation in mouse cone phototransduction [PDF]

, 2011
A negative phototransduction feedback in rods and cones is critical for the timely termination of their light responses and for extending their function to a wide range of light intensities. The calcium feedback mechanisms that modulate phototransduction
Chen, Jeannie, Kefalov, Vladimir J, Sakurai, Keisuke   +2 more
core   +2 more sources

Pseudomonas aeruginosa Exotoxin Y Is a Promiscuous Cyclase That Increases Endothelial Tau Phosphorylation and Permeability*

Journal of Biological Chemistry, 2012
Background: ExoY induces inter-endothelial gaps, although the mechanisms by which this occurs are poorly understood. Results: ExoY synthesized cAMP and cGMP, which caused endothelial Tau hyperphosphorylation, accumulation of insoluble Tau, inter ...
C. Ochoa, M. Alexeyev, V. Pastukh, R. Balczon, T. Stevens   +4 more
semanticscholar   +1 more source