Results 161 to 170 of about 4,029,048 (318)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Slow 5-cycles and their Special Properties Heard in World Music
Analytical Approaches to World MusicThis essay develops and applies a theoretical language for describing a special family of musical cycles that feature five elements at very slow tempos, with the aim of appreciating the listening experiences they afford.
John Roeder
doaj
, 2013 In this chapter we shall analyze how to simulate, within a quasi-dimensional combustion model, the cyclic variability experimentally observed in spark ignition engines. Explicit qualitative comparison with experimental results will be shown. Moreover, we report a nonlinear dynamics analysis of cycle-by-cycle variations in heat release for the simulated
Alejandro Medina +5 more
openaire +1 more source
Ghost sign for Motor Cycle Accesories Ltd. on Belgrave Gate, 2024.
Ghost sign for for Motor Cycle Accessories Ltd. with 'Estd. 1950' on the left and 'Motor Cycle Accessories' on the right. MCA Ltd.
Hyde, Colin
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Business Cycle Theory and Econometrics [PDF]
We outline in turn criticisms made by econometricians of the methods used in empirical business-cycle research and then criticisms made by business-cycle researchers of some methods used by econometricians. The aim is to clarify and in some cases correct
Gregor W. Smith, Allan W. Gregory
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Showcasing life cycle management
Industries following a linear approach assume that ‘if they produce more, they will sell more’. As new trends in production and consumption models emerge due to growing social, environmental and economic pressures, the linear approach is being replaced ...
Cano Londoño, Natalia AndreaCA100002212947868020040454410000-0003-4828-6442da2e1992-e388-11ec-a039-aec0cdf8977c +3 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source