Results 201 to 210 of about 8,652,661 (302)

IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle [PDF]

, 2016
Irene L. Indalao, Takako Sawabuchi, Eiki Takahashi, Hiroshi Kido   +3 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

An emerging clock mechanism in a hydrozoan jellyfish. [PDF]

PLoS Biol
Rosato E.
europepmc   +1 more source

c-Myb Contributes to G₂/M Cell Cycle Transition in Human Hematopoietic Cells by Direct Regulation of Cyclin B1 Expression

, 2007
Yuji Nakata, Susan E. Shetzline, Chizuko Sakashita, Anna Kalota, Ravikumar Rallapalli, Stephen I. Rudnick, Yi Zhang, Stephen G. Emerson, Alan M. Gewirtz   +8 more
openalex   +1 more source

Textural Insights Into the Evolving Lava Dome Cycles at Santiaguito Lava Dome, Guatemala [PDF]

, 2018
Emma Rhodes, Ben Kennedy, Yan Lavallée, Adrian Hornby, M. J. Edwards, Gustavo Chigna   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Atrial Tram Tracks and Ventricular Step Ladder: Decoding the Dot Plot. [PDF]

J Arrhythm
Velayutham R, Bhargav A, Janarthanan B, Selvaraj RJ.   +3 more
europepmc   +1 more source

Correlation of clinicopathological features with immunohistochemical expression of cell cycle regulatory proteins p16 and retinoblastoma: distinct association with keratinisation and differentiation in oral cavity squamous cell carcinoma [PDF]

, 2006
DesiRae Muirhead, Henry T. Hoffman, Robert A. Robinson   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Menstrual Cycle-Related Hormonal Fluctuations in ADHD: Effect on Cognitive Functioning-A Narrative Review. [PDF]

J Clin Med
Wynchank D, Sutrisno RMGTMF, van Andel E, Kooij JJS.   +3 more
europepmc   +1 more source