Results 161 to 170 of about 9,877,914 (299)

Control of light-dependent behaviour in cyanobacteria by the second messenger cyclic di-GMP. [PDF]

Microlife, 2023
Enomoto G, Wallner T, Wilde A.
europepmc   +1 more source

Social Accounting for Work‐Related Injuries: Towards a Sustainable Management of Social Externalities

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The present study seeks to advance the understanding of the determinants of occupational injuries, thereby enhancing both academic knowledge and decision‐making in the management and implementation of occupational health and safety measures.
Rosa María Cañaveras Perea, Ángel Tejada Ponce, María Pilar Sánchez González   +2 more
wiley   +1 more source

The accumulation and growth of Pseudomonas aeruginosa on surfaces is modulated by surface mechanics via cyclic-di-GMP signaling. [PDF]

NPJ Biofilms Microbiomes, 2023
Wang L, Wong YC, Correira JM, Wancura M, Geiger CJ, Webster SS, Touhami A, Butler BJ, O'Toole GA, Langford RM, Brown KA, Dortdivanlioglu B, Webb L, Cosgriff-Hernandez E, Gordon VD.   +14 more
europepmc   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Host cell-based screening assays for identification of molecules targeting Pseudomonas aeruginosa cyclic di-GMP signaling and biofilm formation. [PDF]

Front Microbiol, 2023
Hu Y, Webb JS, An SQ.
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Dual functions: A coumarin-chalcone conjugate inhibits cyclic-di-GMP and quorum-sensing signaling to reduce biofilm formation and virulence of pathogens. [PDF]

mLife, 2023
Zhang Y, Bhasme P, Reddy DS, Liu D, Yu Z, Zhao T, Zheng Y, Kumar A, Yu H, Ma LZ.   +9 more
europepmc   +1 more source

Radiolabeled Coordination Polymer‐Loaded Microneedles for Synergistic Melanoma Brachytherapy–Immunotherapy via STING Activation and Pyroptosis

Exploration, EarlyView.
We developed a dissolvable microneedle patch that locally delivers a radiolabeled coordination polymer designed to simultaneously destroy tumor cells and stimulate antitumor immunity through STING activation and pyroptosis. This strategy significantly inhibited melanoma growth and improved the effectiveness of immune checkpoint therapy, highlighting a ...
Pian Yu, Shijun Xiang, Lu Hao, Jessica C. Hsu, Kaixuan Li, Rongxuan Yan, Ming Zhou, Yongxiang Tang, Ying Peng, Weibo Cai, Cong Peng, Peng Liu, Shuo Hu   +12 more
wiley   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP. [PDF]

Nat Commun, 2022
Schumacher MA, Wörmann ME, Henderson M, Salinas R, Latoscha A, Al-Bassam MM, Singh KS, Barclay E, Gunka K, Tschowri N.   +9 more
europepmc   +1 more source