Results 181 to 190 of about 9,877,914 (299)

Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING. [PDF]

Signal Transduct Target Ther
Wang J, Mrozek A, Hu K, You H, Traverse SE, Lee H, Zeng SX, Pang X, Park H, Lu H.   +9 more
europepmc   +1 more source

Bioinformatic and functional characterization of cyclic-di-GMP metabolic proteins in Vibrio alginolyticus unveils key diguanylate cyclases controlling multiple biofilm-associated phenotypes. [PDF]

Front Microbiol, 2023
Gong XX, Zeng YH, Chen HM, Zhang N, Han Y, Long H, Xie ZY.   +6 more
europepmc   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di-GMP-Specific EAL Phosphodiesterases. [PDF]

Microb Biotechnol
Cao LY, Zhang X, Bai FW, Römling U.
europepmc   +1 more source

Sensing the Messenger: Potential Roles of Cyclic-di-GMP in Rickettsial Pathogenesis. [PDF]

Int J Mol Sci, 2022
Narra HP, Sahni A, Sepuru KM, Alsing J, Sahni SK.   +4 more
europepmc   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

The role of cyclic di-GMP in biomaterial-associated infections caused by commensal Escherichia coli. [PDF]

PLoS One
Li S, Bi C, Xiang B, Wang Z, Yang H, Fu C, Chen L, Chen Y.   +7 more
europepmc   +1 more source

Correction to: control of light-dependent behaviour in cyanobacteria by the second messenger cyclic di-GMP. [PDF]

Microlife, 2023
europepmc   +1 more source

Cyclic di-GMP Signaling Links Biofilm Formation and Mn(II) Oxidation in Pseudomonas resinovorans. [PDF]

mBio, 2022
Piazza A, Parra L, Ciancio Casalini L, Sisti F, Fernández J, Malone JG, Ottado J, Serra DO, Gottig N.   +8 more
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source