Results 151 to 160 of about 117,365 (258)

Metabolic thermodynamics: pertinent reference state and energy potentials

open access: yesThe FEBS Journal, EarlyView.
A recommendation and method to view the energy potentials of metabolites with reference to (green arrow) a biochemical precursor state (in green: water, Mg2+, phosphate, bicarbonate, ammonium, and sulfate, at pH = 7) rather than (the red arrow) the physical–chemical reference state (in grayish red) that is alien to biology, that is, O2, H2, N2 at 1 ...
Hans V. Westerhoff   +21 more
wiley   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

open access: yesThe FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels   +7 more
wiley   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

open access: yesInternational Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad   +2 more
wiley   +1 more source

Nocturnal asthma [PDF]

open access: yes, 1991
Emslander, H.-P.   +7 more
core   +1 more source

Towards an integrated molecular understanding of plant hormones

open access: yesJournal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain   +2 more
wiley   +1 more source

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