Results 181 to 190 of about 117,365 (258)

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

A two-dimensional finite element model of cyclic adenosine monophosphate (cAMP) intracellular signaling. [PDF]

SN Appl Sci, 2019
Stone N, Shettlesworth S, Rich TC, Leavesley SJ, Phan AV.   +4 more
europepmc   +1 more source

Oligomerization of Non‐Activated Nucleotides Under Hot Acidic Wet–Dry Cycling Without Catalytic Agents

ChemSystemsChem, Volume 8, Issue 4, July 2026.
Oligonucleotides form spontaneously through hot wet‐dry cycling of pure non‐activated nucleotides. No catalytic agents were added, and pH was naturally buffered by the nucleotides. Oligonucleotide formation was confirmed and quantified using mass spectrometry, spectroscopy and electrophoresis, establishing a solid baseline for the intrinsic extent of ...
Simon H. J. Eiby, Morten J. Bjerrum, Bálint Hajdu, Laura Da Silva, Peter W. Thulstrup, Tue Hassenkam   +5 more
wiley   +1 more source

Turning Electrode Orientation into a Design Parameter: Gravity‐Driven Convection for Coupling Electrochemical and Enzymatic Reactions

ChemElectroChem, Volume 13, Issue 11, 3 June 2026.
Electrochemically induced density gradients are harnessed to drive gravity‐dependent convection at partially fouled electrodes. By controlling electrode orientation and surface heterogeneity, mass transport is enhanced without external stirring. This enables coupling of electrochemical reactions with enzyme catalysis on insulating domains, exemplified ...
Wathsala Prasadini Kapuralage, Jesse Fletcher, K. Swaminathan Iyer, Simone Ciampi   +3 more
wiley   +1 more source

Beyond Vasospasm: Dual Milrinone and Balloon Angioplasty in Refractory Delayed Cerebral Ischemia Post‐Subarachnoid Hemorrhage

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Cerebral vasospasm is a major complication of aneurysmal subarachnoid hemorrhage and a key contributor to delayed cerebral ischemia, which remains a leading cause of morbidity despite standard therapy with nimodipine and induced hypertension.
Paul Cardozo Gil, Willy Pozo Soto, Alejandro Sengoku Cadima, Pablo Flores, Jorge Botello Marin, Gustavo Averanga, Richy Hurtado Montaño, Nelson Montalvo Flores   +7 more
wiley   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

Cardioprotective effect of spirulina on cafeteria diet‐induced cardiac injury in silico and in vivo study

Journal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4720-4743, June 2026.
Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari, Mohamed‐Amine Jabri, Imen Hammami, Hichem Sebai   +3 more
wiley   +1 more source