Results 241 to 250 of about 73,847 (309)

Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6207-6216, July 2026.
ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay, Ambanna Gowda, Manish Kumar Singh, A. Gopal Rao, Ramesh Duraisamy, Dinesh Gangwani, Jitendra Shukla, Vikas Agarwal, Sandesh Sahebarao Patil, Ambrish C., Satish Babu K. N., Arvind Palawat, Sandip Krishnrao Gofne, Abhay Kumar Sahoo, Pradeep Kumar Rai, Raisa Shaikh, Shruti Saha, Dipak Patil, Pravin Ghadge, Piyush Patel, Lalit Lakhwani, Suyog Mehta, Sadhna Joglekar   +22 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

COCHLEATA controls spatial regulation of cytokinin and auxin during nodule development

New Phytologist, Volume 251, Issue 1, Page 228-244, July 2026.
Nodule development defects in the coch mutant include root‐like structures, reduced colonisation, and vascular disorganisation. Summary Root nodules host nitrogen‐fixing bacteria and likely evolved through modifications of the lateral root program. Members of the NOOT‐BOP‐COCH‐LIKE transcriptional coregulator family suppress root identity in nodules ...
Karen Velandia, Muhammad Nouman Sohail, Tiana E. Scott, Alejandro Correa‐Lozano, Alannah Mannix, Eloise Foo   +5 more
wiley   +1 more source

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

Turning Electrode Orientation into a Design Parameter: Gravity‐Driven Convection for Coupling Electrochemical and Enzymatic Reactions

ChemElectroChem, Volume 13, Issue 11, 3 June 2026.
Electrochemically induced density gradients are harnessed to drive gravity‐dependent convection at partially fouled electrodes. By controlling electrode orientation and surface heterogeneity, mass transport is enhanced without external stirring. This enables coupling of electrochemical reactions with enzyme catalysis on insulating domains, exemplified ...
Wathsala Prasadini Kapuralage, Jesse Fletcher, K. Swaminathan Iyer, Simone Ciampi   +3 more
wiley   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, Volume 13, Issue 32, 9 June 2026.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Sex differences are increasingly recognized as central to the biology of Alzheimer's disease (AD), yet the mechanisms through which they shape brain metabolism and disease vulnerability remain incompletely understood. Brain glucose hypometabolism is a core hallmark of AD and emerges decades before clinical decline, but accumulating evidence ...
Marjan Ramezan, Aphrodite Demetriou, Sara Nicole Burke, Ivan Nalvarte, Andrew C. Shin   +4 more
wiley   +1 more source

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik, Kay Jüngling, Sven G. Meuth, Thomas Budde, Marta Méndez‐Couz   +4 more
wiley   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Caffeine and Headache: Exploring the Multifaceted Relationship

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Purpose To explore the multifaceted relationship between caffeine and headache disorders, focusing on its dual role as both an analgesic and a potential trigger and to summarize the mechanisms underlying its anti‐nociceptive effects. Method This narrative review synthesizes evidence from experimental, clinical, and epidemiological studies on ...
Mona Hussein, Amr Hassan, Salsabil Abo Al‐Azayem, Janu Thuraiaiyah, Henrik Winther Schytz, Anter Mothenna Abdullah Nasser, Rehab Magdy   +6 more
wiley   +1 more source