Results 41 to 50 of about 986,227 (410)
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
Proceedings of the National Academy of Sciences of the United States of America, 1986 We have examined the regulation of somatostatin gene expression by cAMP in PC12 rat pheochromocytoma cells transfected with the rat somatostatin gene. Forskolin at 10 microM caused a 4-fold increase in somatostatin mRNA levels within 4 hr of treatment in
M. Montminy +4 more
semanticscholar +1 more source
Annals of Surgery, 1976 Cyclic AMP is believed to be the intracellular agent which mediates the action of many hormones on their target cell. The mechanisms by which the nucleotide controls glycogen metabolism in liver and skeletal muscle seem to be firmly established. Data relevant to this area of research are selectively reviewed.
openaire +3 more sources
Guanidinium phenylarsonate–guanidine–water (1/1/2)
Acta Crystallographica Section E, 2010 In the structure of the title compound, CH6N3+·C6H6AsO3−·CH5N3·2H2O, the phenylarsonate anion participates in two R22(8) cyclic hydrogen-bonding interactions, one with a guanidinium cation, the other with a guanidine ...
Graham Smith, Urs D. Wermuth
doaj +1 more source
Short PDE4 Isoforms as Drug Targets in Disease
Frontiers in Bioscience-Landmark, 2023 The second messenger, cyclic adenosine monophosphate (cAMP), is a master regulator of signal transduction that maintains cell homeostasis. A fine balance between cAMP synthesis by adenylyl cyclase and degradation by phosphodiesterases (PDEs) underpins ...
Elka Kyurkchieva, George S. Baillie
doaj +1 more source
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling [PDF]
Journal of Biological Chemistry, 2003 No abstract available.
Conti, Marco +5 more
openaire +4 more sources
4-Carbamoylpiperidinium phenylacetate hemihydrate
Acta Crystallographica Section E, 2010 The asymmetric unit of the title compound, C6H13N2O+·C8H7O2−·0.5H2O, comprises two isonipecotamide cations, two phenylacetate anions and a water molecule of solvation.
Urs D. Wermuth, Graham Smith
doaj +1 more source
Journal of the American Chemical Society, 2013 Cyclic dinucleotides are an important class of signaling molecules that regulate a wide variety of pathogenic responses in bacteria, but tools for monitoring their regulation in vivo are lacking.
C. A. Kellenberger +3 more
semanticscholar +1 more source
Phosphoproteins associated with cyclic nucleotide stimulation of ciliary motility in Paramecium [PDF]
, 1990 Permeabilized, MgATP-reactivated cells of Paramecium (models) respond to cyclic AMP and cyclic GMP by increasing forward swimming speed. In association with the motile response, cyclic AMP and 8-bromo-cyclic GMP (8-Br-cyclic GMP) stimulated protein ...
Bonini, Nancy M., Nelson, David L.
core
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Acta Crystallographica Section E, 2010 The title compound, CH6N3+·C7H4NO4−, an anhydrous guanidinium salt, shows a N—H...O hydrogen-bond network in which the guanidinium cation is involved in three cyclic R21(6) hydrogen-bonding associations with separate ...
Graham Smith, Urs D. Wermuth
doaj +1 more source