Results 101 to 110 of about 672 (207)
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Cyclic, LCD, and Self-Dual Codes over the Non-Frobenius Ring GR(p2,m)[u]/〈u2,pu〉
MathematicsLet p be a prime number and m be a positive integer. In this paper, we investigate cyclic codes of length n over the local non-Frobenius ring R=GR(p2,m)[u], where u2=0 and pu=0.
Sami Alabiad, Alhanouf Ali Alhomaidhi
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
On the Existence of Cyclic and Pseudo-Cyclic MDS Codes
European Journal of Combinatorics, 1998 A linear code \(C\) of length \(n\) and dimension \(k\) over the Galois field \(\mathbb{F}_q\), denoted as an \([n,k]_q\) code, is called MDS if its minimum distance \(d\) equals \(n-k+1\). \(C\) is called pseudo-cyclic (the names semi-cyclic and constacyclic are also in use) if there exists an \(\alpha\in \mathbb{F}_q \setminus\{0\}\) such that \((c_1,
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Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
FpRS-Additive Cyclic Codes are Asymptotically Good
IEEE AccessIn coding theory, the rate and the relative minimum distance are two important invariants to assess a family of codes’ asymptotic characteristics.
Bhanu Pratap Yadav
doaj +1 more source
On threshold decoding of cyclic codes
Information and Control, 1968 Bose-Chaudhuri-Hocquenghem (BCH) codes are very powerful random error-correcting techniques. We have investigated whether all BCH codes can be L-step orthogonalized, and have found a specific class of double error-correcting BCH codes which cannot be L-step orthogonalized. We show further that all BCH codes with length qm − 1, where q is a power of any
openaire +2 more sources