Results 31 to 40 of about 89,462 (268)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Coupling effects of cyclic confining pressure and loading frequency on deformation behavior of saturated soft clay under intermittent cyclic loading

Yantu gongcheng xuebao
After the train passes away, the subgrade soils undergo cyclic loading and intermittent periods. The existence of the intermittent period can also affect the mechanical properties of soil.
HUANG Juehao 1, 2 , ZHONG Yu 3, WU Jiaming 4, MENG Chao 5, 1, CHEN Jian 1, 2, FU Xiaodong 1, 2
doaj   +1 more source

Analysis of fracture deformation field and energy evolution of granite after high confining pressure cyclic load pre-damage

Royal Society Open Science, 2021
Considering the recent developments of deep mining, investigating the rock properties under high ground stress periodic load is highly demanded. Studies show that these characteristics are important factors affecting the long-term steadiness of rock ...
Dong-Jie Yang, Jian-Hua Hu, Guan-Ping Wen, Ping-Ping Zeng   +3 more
semanticscholar   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cyclic Behavior of Calcareous Sand from the South China Sea

Journal of Marine Science and Engineering, 2021
This study examines the cyclic behavior of calcareous sand obtained from the South China Sea. A series of undrained cyclic triaxial tests were performed on the calcareous sand with various relative densities, cyclic stress ratios, and effective confining
Lu Liu, Xiaofei Yao, Zhanpeng Ji, Hongmei Gao, Zhihua Wang, Zhifu Shen   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Experimental study on deformation behaviors of saturated soft clay under intermittent cyclic loading with various drained conditions

Yantu gongcheng xuebao
In the previous studies, the cyclic triaxial tests under intermittent cyclic loading are used to study the deformation characteristics of soft clay under traffic loads. Both confining pressure and deviator stress vary cyclically in the stress field under
HUANG Juehao 1, 2, XU Linfeng 3, 1, LU Yuan 5, YAN Wenlong 4, 1, CHEN Jian 1, 2, FU Xiaodong 1, 2
doaj   +1 more source

Experimental assessment on deformation and anisotropic behavior of saturated sandstone under cyclic loading [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2017
The research was performed to assess the effects of cyclic loading on deformation behavior of saturated Phu Kradung sandstone of the Khorat Group under confining pressure and rock anisotropy.
Wimon Sukplum, Ladda Wannakao
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source