Results 51 to 60 of about 20,307 (290)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Experimental study on deformation behaviors of saturated soft clay under intermittent cyclic loading with various drained conditions

Yantu gongcheng xuebao
In the previous studies, the cyclic triaxial tests under intermittent cyclic loading are used to study the deformation characteristics of soft clay under traffic loads. Both confining pressure and deviator stress vary cyclically in the stress field under
HUANG Juehao 1, 2, XU Linfeng 3, 1, LU Yuan 5, YAN Wenlong 4, 1, CHEN Jian 1, 2, FU Xiaodong 1, 2
doaj   +1 more source

Cyclic behaviour and resistance of saturated sand under non-symmetrical loading conditions [PDF]

, 2011
This paper reports findings from an experimental study that aimed to investigate the undrained behaviour of sand in non-symmetrical cyclic loading, and to clarify the role of initial static shear in liquefaction resistance.
Sze, HY, Yang, J
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Road Performance and Water-Softening Characteristics of Stabilized Soil under Cyclic Loading

Zhongwai Gonglu
To effectively deal with waste soil and reduce environmental pollution, this paper took a road engineering project in Shaoxing as the research object and conducted a cyclic triaxial incremental loading test on the undisturbed lime soil under undrained ...
HU Hong, LI Zongheng, FENG Yong, CAO Zhigang, LIU Yaoxing   +4 more
doaj   +1 more source

Identifying the Impact Factors of the Dynamic Strength of Mudded Intercalations during Cyclic Loading

Advances in Civil Engineering, 2018
Despite reports on previous research associated with the dynamic strength of mudded intercalations during cyclic loading, a systematic investigation of the impact factors of this strength is still valuable. This work aimed at experimentally revealing the
Changbin Yan, Xiao Xu, Lei Huang
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Classification and Fractal Characteristics of Limestone Fragments Obtained in Conventional Compression and Cyclic Loading Tests under Uniaxial and Triaxial Conditions

Advances in Materials Science and Engineering, 2020
The mechanical response characteristics of rocks under cyclic loading conditions are crucial factors for evaluating and analyzing the stability of rock mass during underground excavation. In this study, based on fractal theory and a series of tests using
Rui Yang, Xiaodi Wang, Hao Zha, Xiuzhang Yang, Yang Zhang, Gang Huang, Yongjie Yang   +6 more
doaj   +1 more source

Experimental study of strain accumulation of silica sand in a cyclic triaxial test [PDF]

, 2014
The experimental and phenomenological investigation of the elasto-plastic long-term behaviour of soils under dynamic loading is important for the development of risk analysis tools and numerical accumulation models for settlement prediction.
Benoot, Jelle, Degrande, Geert, Haegeman, Wim   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source