Results 61 to 70 of about 20,307 (290)
Loading-unloading responses of non-persistent flawed granite subjected to cyclic disturbances
Journal of Rock Mechanics and Geotechnical EngineeringDuring geotechnical construction, flawed rock masses experience dynamic cyclic disturbances, leading to cumulative deformation and progressive damage.
Tingting Liu +5 more
doaj +1 more source
Sleeper end resistance of ballasted railway tracks [PDF]
, 2014 This paper describes model tests used to investigate how ballast shoulder width and height contribute to a railway sleeper’s resistance to lateral movement for a range of shoulder widths and heights.
Bhandari, A.R., Le Pen, L., Powrie, W.
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Advances in Civil Engineering, 2020 Brittle failure of hard rock poses a serious threat to the stability of surrounding rock in deep underground engineering. In order to study the deformation and failure characteristics of deep buried granite under high confining pressure cyclic loading ...
Jun Zhao, Tan Zhang
doaj +1 more source
Resilient Modulus Characterization of Alaskan Granular Base Materials [PDF]
, 2010 INE/AUC 11 ...
Li, Lin, Liu, Juanyu, Zhang, Xiong
core
Effect of initial relative density on the post-liquefaction behaviour of sand [PDF]
, 2017 Understanding the behaviour of soils under cyclic/dynamic loading has been one of the challenging topics in geotechnical engineering. The response of liquefiable soils has been well studied however, the post liquefaction behaviour of sands needs better ...
Bhattacharya, Subhamoy +2 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Behavior of confined granular beds under cyclic thermal loading
, 2019 We investigate the mechanical behavior of a confined granular packing of irregular polyhedral particles under repeated heating and cooling cycles by means of numerical simulations with the Non-Smooth Contact Dynamics method.
Giacomazzi, Elena +5 more
core +1 more source
Slope stability in slightly fissured claystones and marls [PDF]
, 2015 The final publication is available at Springer via http://dx.doi.org/10.1007/s10346-014-0526-5The paper deals with the behavior of some characteristic soft rocks found in the Iberian Peninsula.
Alonso Pérez de Agreda, Eduardo +1 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source