Results 61 to 70 of about 473 (205)

Analysis of permeability evolution law of gas-bearing coal under cyclic loading condition

Meitan kexue jishu
In order to explore the permeability evolution law of gas-bearing coal under different cyclic loading and unloading conditions, raw coal samples were taken as the research object, and cyclic loading-unloading experiments of gas-bearing coal were designed
Dengke WANG, Haohang FENG, Jianping WEI, Xu CHEN, Zhigang JIANG, Xiuzhu YUAN, Yun BAI, Tanggen CAO, Wenchao XIONG   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hydromechanical Coupling Characteristics of the Fractured Sandstone under Cyclic Loading-Unloading

Geofluids, 2020
The mechanical and hydraulic properties of rock mass play a crucial role in underground engineering. To study the effect of hydraulic pressure, confining pressure, and axial cyclic loading-unloading on variation of the deformation and permeability in ...
Tong Zhang, Yang Liu, Ke Yang, Ming Tang, Xiang Yu, Fei Yu   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Evolution of particle crushing of carbonate sands under cyclic triaxial stress path

Yantu gongcheng xuebao, 2019
The carbonate sand is widely distributed in the South China Sea and used as the fill materials for land reclamation. Carbonate sand particles are fragile and can be easily crushed, making the carbonate sand exhibit distinctive mechanical behaviors ...
WANG Gang 1,2, ZHA Jing-jing 1,2, WEI Xing 3
doaj   +1 more source

Dynamic Characteristics of Saturated Soft Clay under Constant Confining Pressure Cyclic Loading

IOP Conference Series: Earth and Environmental Science, 2020
Abstract The research on the dynamic characteristics of soft clay under cyclic loading has high value. This paper takes Ningbo saturated soft clay as the research object and uses the GCTS true triaxial test system to analyze the effects of consolidated confining pressure and cyclic deviator stress on the axial cumulative strain.
Yuan Lu, Fusheng Liu, Youyan Bian, Yu Zhong, Bin Chen, Juehao Huang, Jian Chen   +6 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Accumulated Deformation of Gravel Filler of Subgrade under Cyclic Loading

工程科学与技术, 2018
Under cyclic loading of the train, the cumulative deformation of the subgrade will be produced, which causes the track irregularity and affects the comfort and safety of the train.
Yangbo LI, Jiasheng ZHANG, Zhihui ZHU, Xuan WANG, Zhaosheng YU   +4 more
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source