Results 41 to 50 of about 2,536 (250)

Road Performance and Water-Softening Characteristics of Stabilized Soil under Cyclic Loading

Zhongwai Gonglu
To effectively deal with waste soil and reduce environmental pollution, this paper took a road engineering project in Shaoxing as the research object and conducted a cyclic triaxial incremental loading test on the undisturbed lime soil under undrained ...
HU Hong, LI Zongheng, FENG Yong, CAO Zhigang, LIU Yaoxing   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Experimental study on deformation behaviors of overconsolidated clay under cyclic confining pressure

Yantu gongcheng xuebao, 2021
Traffic loading is usually simulated by single cyclic deviator stress. However, the vertical normal stress and horizontal stress acting on the soil elements are all varied cyclically under traffic loading.
HUANG Jue-hao 1, 2, 3, 4, WANG Ying-wu 5, CHEN Jian 1, 2, 3, 4, 6, 7, LIU Fu-sheng 8, HOU Feng 8, FU Xiao-dong 1, 2, MA Chao 1
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Comparison of Cyclic Triaxial Tests with Constant and Variable Cell Pressure

J
Cyclic triaxial tests are often used to evaluate the behavior of soils under seismic loads. The stress conditions imposed on a soil specimen during a cyclic triaxial test, however, are very different than those acting on an element of soil during an ...
Carmine P. Polito
doaj   +1 more source

Identifying the Impact Factors of the Dynamic Strength of Mudded Intercalations during Cyclic Loading

Advances in Civil Engineering, 2018
Despite reports on previous research associated with the dynamic strength of mudded intercalations during cyclic loading, a systematic investigation of the impact factors of this strength is still valuable. This work aimed at experimentally revealing the
Changbin Yan, Xiao Xu, Lei Huang
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Loading-unloading responses of non-persistent flawed granite subjected to cyclic disturbances

Journal of Rock Mechanics and Geotechnical Engineering
During geotechnical construction, flawed rock masses experience dynamic cyclic disturbances, leading to cumulative deformation and progressive damage.
Tingting Liu, Chao Zhang, Luyang Ding, Kun Xu, Xinping Li, Wenxu Huang   +5 more
doaj   +1 more source

Effect of confining pressure on ballast degradation and deformation under cyclic triaxial loading

Géotechnique, 2007
Traditional railway foundations or substructures have become increasingly overloaded in recent years, owing to the introduction of faster and heavier trains. A lack of substructure re-engineering has resulted in maintenance cycles becoming more frequent and increasingly expensive.
Lackenby, J., Indraratna, Buddhima, McDowell, G., Christie, D.   +3 more
openaire   +3 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source