Results 41 to 50 of about 89,462 (268)

Road Performance and Water-Softening Characteristics of Stabilized Soil under Cyclic Loading

Zhongwai Gonglu
To effectively deal with waste soil and reduce environmental pollution, this paper took a road engineering project in Shaoxing as the research object and conducted a cyclic triaxial incremental loading test on the undisturbed lime soil under undrained ...
HU Hong, LI Zongheng, FENG Yong, CAO Zhigang, LIU Yaoxing   +4 more
doaj   +1 more source

Mechanical Behavior and Damage Evolution for Granite Subjected to Cyclic Loading

Advances in Materials Science and Engineering, 2018
This paper focuses on the mechanical behavior and damage evolution of Huashan granite subjected to cyclic loading. Four levels of confining pressure (0, 15, 25, and 35 MPa) were applied during cyclic axial loading by using a Rock Test System (MTS815 ...
Zhiliang Wang, Jikang Yao, Nuocheng Tian, Jingbin Zheng, Peng Gao   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Comparison of Cyclic Triaxial Tests with Constant and Variable Cell Pressure

J
Cyclic triaxial tests are often used to evaluate the behavior of soils under seismic loads. The stress conditions imposed on a soil specimen during a cyclic triaxial test, however, are very different than those acting on an element of soil during an ...
Carmine P. Polito
doaj   +1 more source

Identifying the Impact Factors of the Dynamic Strength of Mudded Intercalations during Cyclic Loading

Advances in Civil Engineering, 2018
Despite reports on previous research associated with the dynamic strength of mudded intercalations during cyclic loading, a systematic investigation of the impact factors of this strength is still valuable. This work aimed at experimentally revealing the
Changbin Yan, Xiao Xu, Lei Huang
doaj   +1 more source

Experimental study on deformation behaviors of overconsolidated clay under cyclic confining pressure

Yantu gongcheng xuebao, 2021
Traffic loading is usually simulated by single cyclic deviator stress. However, the vertical normal stress and horizontal stress acting on the soil elements are all varied cyclically under traffic loading.
HUANG Jue-hao 1, 2, 3, 4, WANG Ying-wu 5, CHEN Jian 1, 2, 3, 4, 6, 7, LIU Fu-sheng 8, HOU Feng 8, FU Xiao-dong 1, 2, MA Chao 1
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Loading-unloading responses of non-persistent flawed granite subjected to cyclic disturbances

Journal of Rock Mechanics and Geotechnical Engineering
During geotechnical construction, flawed rock masses experience dynamic cyclic disturbances, leading to cumulative deformation and progressive damage.
Tingting Liu, Chao Zhang, Luyang Ding, Kun Xu, Xinping Li, Wenxu Huang   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source