Results 41 to 50 of about 473 (205)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Experimental study on the mechanical properties and deformation failure characteristics of sandstone under graded equal amplitude cyclic loading and unloading

open access: yesScientific Reports
To investigate the effects of graded equal amplitude cyclic loading on rock deformation and failure, this study examines the influence of confining pressure and upper limit cyclic stress on the deformation parameters, stress–strain hysteresis curves, and
Zhiwei Ni   +5 more
doaj   +1 more source

Comparison of Cyclic Triaxial Tests with Constant and Variable Cell Pressure

open access: yesJ
Cyclic triaxial tests are often used to evaluate the behavior of soils under seismic loads. The stress conditions imposed on a soil specimen during a cyclic triaxial test, however, are very different than those acting on an element of soil during an ...
Carmine P. Polito
doaj   +1 more source

Identifying the Impact Factors of the Dynamic Strength of Mudded Intercalations during Cyclic Loading

open access: yesAdvances in Civil Engineering, 2018
Despite reports on previous research associated with the dynamic strength of mudded intercalations during cyclic loading, a systematic investigation of the impact factors of this strength is still valuable. This work aimed at experimentally revealing the
Changbin Yan, Xiao Xu, Lei Huang
doaj   +1 more source

Experimental study on deformation behaviors of overconsolidated clay under cyclic confining pressure

open access: yesYantu gongcheng xuebao, 2021
Traffic loading is usually simulated by single cyclic deviator stress. However, the vertical normal stress and horizontal stress acting on the soil elements are all varied cyclically under traffic loading.
HUANG Jue-hao 1, 2, 3, 4, WANG Ying-wu 5, CHEN Jian 1, 2, 3, 4, 6, 7, LIU Fu-sheng 8, HOU Feng 8, FU Xiao-dong 1, 2, MA Chao 1
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Loading-unloading responses of non-persistent flawed granite subjected to cyclic disturbances

open access: yesJournal of Rock Mechanics and Geotechnical Engineering
During geotechnical construction, flawed rock masses experience dynamic cyclic disturbances, leading to cumulative deformation and progressive damage.
Tingting Liu   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Mechanism of Micro and Macro Mechanics in Brittle Rocks During Cyclic Creep Under High Seepage Pressure

open access: yes工程科学与技术, 2023
Cyclic creep mechanical properties of brittle rock under the combined influence of high seepage pressure, confining pressure, and cyclic axial loading and unloading are of great significance to the stability evaluation of surrounding rock in deep ...
Xiaozhao LI   +3 more
doaj  

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