Results 71 to 80 of about 20,307 (290)

Hydraulic conductivity of a dense prehydrated geosynthetic clay liner [PDF]

, 2015
Dense prehydrated geosynthetic clay liners (DPH-GCLs) are a particular type of GCL which, unlike conventional GCLs manufactured with dry bentonite, contain bentonite prehydrated during manufacturing.
Di Emidio, Gemmina, Mazzieri, Francesco
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Hydromechanical Coupling Characteristics of the Fractured Sandstone under Cyclic Loading-Unloading

Geofluids, 2020
The mechanical and hydraulic properties of rock mass play a crucial role in underground engineering. To study the effect of hydraulic pressure, confining pressure, and axial cyclic loading-unloading on variation of the deformation and permeability in ...
Tong Zhang, Yang Liu, Ke Yang, Ming Tang, Xiang Yu, Fei Yu   +5 more
doaj   +1 more source

Study on the mechanical properties of unloading damaged sandstone under cyclic loading and unloading

Scientific Reports, 2023
To reveal the mechanical properties of rocks under stress disturbance and unloading confining pressure, conventional triaxial compression tests, triaxial compression tests on unloading damaged sandstone, and cyclic loading and unloading tests on ...
Hengbin Zhang, Lehua Wang, Jianlin Li, Huafeng Deng, Xiaoliang Xu   +4 more
doaj   +1 more source

Effect of confining pressure on ballast degradation and deformation under cyclic triaxial loading

Géotechnique, 2007
Traditional railway foundations or substructures have become increasingly overloaded in recent years, owing to the introduction of faster and heavier trains. A lack of substructure re-engineering has resulted in maintenance cycles becoming more frequent and increasingly expensive.
Lackenby, J., Indraratna, Buddhima, McDowell, G., Christie, D.   +3 more
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Geotechnical behavior of mudstones from the Shimanto and Boso accretionary complexes, and implications for the Nankai accretionary prism [PDF]

, 2014
Triaxial shear tests on mudstone samples from the Shimanto Belt and the Boso accretionary complexes (SW Japan and central Japan) were carried out. Pre-exhumation burial depths in the two paleo-accretionary prisms were up to 9,000 m and about 1,000 m for
Behrmann, Jan H., Kitamura, Yujin, Lempp, Christof, Schumann, Kai, Stipp, Michael, Yamamoto, Yuzuru   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of permeability evolution law of gas-bearing coal under cyclic loading condition

Meitan kexue jishu
In order to explore the permeability evolution law of gas-bearing coal under different cyclic loading and unloading conditions, raw coal samples were taken as the research object, and cyclic loading-unloading experiments of gas-bearing coal were designed
Dengke WANG, Haohang FENG, Jianping WEI, Xu CHEN, Zhigang JIANG, Xiuzhu YUAN, Yun BAI, Tanggen CAO, Wenchao XIONG   +8 more
doaj   +1 more source