Results 61 to 70 of about 103,875 (262)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

On the geometry underlying a real Lie algebra representation [PDF]

open access: yes, 2012
Let $G$ be a real Lie group with Lie algebra $\mathfrak g$. Given a unitary representation $\pi$ of $G$, one obtains by differentiation a representation $d\pi$ of $\mathfrak g$ by unbounded, skew-adjoint operators.
Le-Bert, Rodrigo Vargas
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Simple One-Step Method to Synthesize Polypyrrole-Indigo Carmine-Silver Nanocomposite

open access: yesJournal of Chemistry, 2016
A nanocomposite of indigo carmine doped polypyrrole/silver nanoparticles was obtained by a one-step electrochemical process. The nanocomposite was characterized by scanning electron microscopy, infrared spectroscopy, ultraviolet-visible-near infrared ...
Lara Fernandes Loguercio   +5 more
doaj   +1 more source

Electrochemical Behavior and Antioxidant and Prooxidant Activity of Natural Phenolics

open access: yesMolecules, 2007
We have investigated the electrochemical oxidation of a number natural phenolics (salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, protocatechuic acid, o-coumaric acid, m-coumaric acid, p-coumaric acid, caffeic acid, quercetin and rutin ...
Marija Todorović   +3 more
doaj   +1 more source

Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation. [PDF]

open access: yesPLoS ONE, 2012
Bacterial β-lactamase enzymes are in large part responsible for the decreased ability of β-lactam antibiotics to combat infections. The inability to overcome β-lactamase mediated resistance spurred the development of inhibitors with penems and penam ...
Wei Ke   +6 more
doaj   +1 more source

Dual generators of the fundamental group and the moduli space of flat connections

open access: yes, 2006
We define the dual of a set of generators of the fundamental group of an oriented two-surface $S_{g,n}$ of genus $g$ with $n$ punctures and the associated surface $S_{g,n}\setminus D$ with a disc $D$ removed.
Barut A O   +12 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Why is phenanthrene more stable than anthracene?

open access: yesMacedonian Journal of Chemistry and Chemical Engineering, 2007
By means of a recently developed molecular-orbital-based method it is possible to estimate the energy effects of individual cycles, as well as pairs, triplets, etc. of cycles in polycyclic conjugated molecules.
Ivan Gutman, Sonja Stanković
doaj   +1 more source

Fusion systems on bicyclic 2-groups [PDF]

open access: yes, 2014
We classify all (saturated) fusion systems on bicyclic 2-groups. Here, a bicyclic group is a product of two cyclic subgroups. This extends previous work on fusion systems on metacyclic 2-groups (see [Craven-Glesser, 2012] and [Sambale, 2012]).
Sambale, Benjamin
core  

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