Results 51 to 60 of about 1,609,424 (285)

Estimating Degradation Costs for Non-Cyclic Usage of Lithium-Ion Batteries

open access: yesApplied Sciences, 2020
Estimating the degradation costs of lithium-ion batteries is essential to the designs of many systems because batteries are increasingly used in diverse applications.
Tomás Cortés-Arcos   +2 more
doaj   +1 more source

Performance Evaluation of Reinforced Concrete Columns under Simultaneously Combined Fire and Cyclic Loads

open access: yesBuildings, 2022
Reinforced concrete (RC) structures could suffer from the combined action of fires, earthquakes, and other loads during their life cycle; more importantly, coupled disasters lead to further deterioration and damage to structural performance.
Qingjun Chen, Yu Jiang
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Post-cyclic Strength Degradation of Undisturbed and Remolded Marine Silty Clay

open access: yes, 2008
A series of static and cyclic-static tri-axial compression tests under consolidated-undrained conditions are carried out to study the characteristics of post-cyclic strength of the undisturbed and the remolded samples of marine silty clay.
Wang SY, 王淑云, 鲁晓兵
core   +2 more sources

The influence of alternating cyclic dynamic loads with different low frequencies on the bio-corrosion behaviors of AZ31B magnesium alloy in vitro

open access: yesBioactive Materials, 2022
The real physiological environment of human body is complicated with different degrees and forms of dynamic loads applied to implanted medical devices due to the daily activities of the patients, which would have impacts on the degradation behaviors of ...
Linyuan Han   +8 more
doaj   +1 more source

Shear Strength and Stiffness Degradation of Geomaterials in Cyclic Loading

open access: yesSoils and Rocks, 2016
Cyclic loading on civil structures can lead to a reduction of strength and stiffness in the loaded materials. The life span of many cyclically loaded structures such as wind turbines, high-speed train tracks and bridges strongly depends on the foundation.
Robert Pytlik, Stefan V. Baars
openaire   +2 more sources

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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