Results 101 to 110 of about 18,412 (234)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure [PDF]

, 2011
Novel beta-aminocyclobutanecarboxylic acid derivatives were prepared via a sequential solvent-free aza-Michael addition of benzophenone imine across 3-halopropylidenemalonates and base-induced ring closure.
Aitken, Appella, Brannock, Caine, Choudhary, Declerck, Fernandes, Fernandes, Fernandes, Frackenpohl, Fülöp, Fülöp, Gademann, Gauzy, Gauzy, Gellman, Gorrea, Hall, Imanzadeh, Izquierdo, Kiss, Krapcho, Kuhl, Lehnert, Liu, Mangelinckx, Mangelinckx, Mangelinckx, Mangelinckx, Martinek, Martín-Vilà, Mittendorf, Norbert De Kimpe, Oki, Palko, Rúa, Seebach, Seebach, Su, Sulmon, Sven Mangelinckx, Tamara Meiresonne, Torres, Trabocchi, White   +44 more
core   +1 more source

Chemical Ligation of Backbone N‐hydroxylated Peptides

Chemistry – A European Journal, EarlyView.
Peptide backbone N‐hydroxylation enables sequence‐agnostic fragment ligation via hydroxamate O‐acyl capture and O→N acyl transfer in water. Broad tolerance of sterically demanding nucleophilic residues is observed, and reductive N─O cleavage restores the native amide bond.
Natalia Cano‐Sampaio, Juan R. Del Valle   +1 more
wiley   +1 more source

Bayesian analysis of variable-order, reversible Markov chains

, 2011
We define a conjugate prior for the reversible Markov chain of order $r$. The prior arises from a partially exchangeable reinforced random walk, in the same way that the Beta distribution arises from the exchangeable Poly\'{a} urn.
Bacallado, Sergio
core   +1 more source

Computational approaches to understanding the self-assembly of peptide-based nanostructures [PDF]

, 2015
The interest in the self-assembly of peptide-based systems has grown significantly over the past 10–15 years, as more and more applications are shown to benefit from the useful properties of the amino acid based monomers.
Barz, Beke, Bellesia, Blanco-Canosa, Brooks, Cao, Carmichael, Case, Castelletto, Chapman, Chen, Colombo, Cornell, Cote, Debnath, der Spoel, Eckes, Engels, Engin, Felice, Filot, Fleming, Fleming, Frederix, Frederix, Garcia-Fandino, Gorbitz, Gorbitz, Gough, Grimme, Guo, Guo, Han, Heinz, Heinz, Heinz, Hirst, Hughes, Hughes, Jayawarna, Jorgensen, Jun, Khurana, Kim, Lee, Lee, Lee, Li, Liberato, Liu, Mackerell, MacKerell, Marchesan, Marchesan, Marchesan, Marchesan, Marchesan, Marrink, Matthes, Mayo, Mondal, Montenegro, Monticelli, Morris, Mu, Mu, Murase, Nowinski, Nuansing, Orbach, Pashuck, Ponder, Qu, Rauschenberg, Raz, Reches, Reches, Rymer, Scanlon, Schafer, Seo, Shin, Smith, So, Stendahl, Sun, Tamamis, Tanford, Tsai, Tsonchev, Tsonchev, Tuttle, Velichko, Vijayaraj, Villa, Villa, Wang, Weiner, Weiner, Williams, Xu, Xu, Yu, Yu, Zhang, Zhang, Zhao, Zhao, Zhao, Zou   +109 more
core   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Ga and Gß Proteins Regulate the Cyclic AMP Pathway That Is Required for Development and Pathogenicity of the Phytopathogen Mycosphaerella graminicola [PDF]

We identified and functionally characterized genes encoding three G alpha proteins and one G beta protein in the dimorphic fungal wheat pathogen Mycosphaerella graminicola, which we designated MgGpa1, MgGpa2, MgGpa3, and MgGpb1, respectively.
Kema, G.H.J., Lee, T.A.J., van der, M'Barek, S., Ben, Mehrabi, A., Waalwijk, C., Wit, P.J.G.M., de   +5 more
core   +2 more sources

Almond (Amygdalus communis L.) Peptides Improve Scopolamine‐Induced Learning and Memory Impairment in Mice

Food Safety and Health, EarlyView.
Figure Schematic showing the improvement of almond peptides on learning and memory impairment induced by scopolamine in mice. Almond peptides (APs) could improve the learning and memory in scopolamine‐induced mice by maintaining cholinergic system homeostasis and regulating Nrf2/Keap1 signaling pathway, via activating the Nrf2 transcription factor and ...
Xin Shang, Wenjing Gao, Caiyun Zhao, Bin Li, Jintian Guo, Jingteng Wang, Minwei Zhang, Yinghua Fu   +7 more
wiley   +1 more source

Proline cis-​trans isomerization and its implications for the dimerization of analogues of cyclopeptide stylostatin 1: a combined computational and experimental study [PDF]

, 2016
Cis and trans proline conformers are often associated with dramatic changes in the biological function of peptides. A slow equilibrium between cis and trans Ile-Pro amide bond conformers occurs in constrained derivatives of the native marine cyclic ...
Campanera Alsina, Josep Maria, Cruz, M., Diez Pascual, Anna, Feliz Rodenas, Miguel, Flores-Morales, P., Gonzalez, Teresa, López Martínez, Carlos   +6 more
core   +1 more source