Proline-Based Cyclic Dipeptides from Korean Fermented Vegetable Kimchi and from Leuconostoc mesenteroides LBP-K06 Have Activities against Multidrug-Resistant Bacteria [PDF]
Frontiers in Microbiology, 2017 Lactobacillus plantarum and Leuconostoc mesenteroides play a prominent role as functional starters and predominant isolates in the production of various types of antimicrobial compound-containing fermented foods, especially including kimchi.
Min-Kyu Kwak +3 more
doaj +7 more sources
The tRNA-Dependent Biosynthesis of Modified Cyclic Dipeptides [PDF]
International Journal of Molecular Sciences, 2014 In recent years it has become apparent that aminoacyl-tRNAs are not only crucial components involved in protein biosynthesis, but are also used as substrates and amino acid donors in a variety of other important cellular processes, ranging from bacterial cell wall biosynthesis and lipid modification to protein turnover and secondary metabolite assembly.
Tobias W Giessen +2 more
exaly +7 more sources
Effects of hydroxyl group in cyclo(Pro-Tyr)-like cyclic dipeptides on their anti-QS activity and self-assembly [PDF]
iScience, 2023 Summary: We investigated the influence of hydroxyl groups on the anti-quorum-sensing (anti-QS) and anti-biofilm activity of structurally similar cyclic dipeptides, namely cyclo(L-Pro-L-Tyr), cyclo(L-Hyp-L-Tyr), and cyclo(L-Pro-L-Phe), against Pseudomonas
Li Li +6 more
doaj +4 more sources
Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides [PDF]
Marine Drugs, 2022 Quorum sensing (QS) can regulate the pathogenicity of bacteria and the production of some virulence factors. It is a promising target for screening to find anti-virulence agents in the coming post-antibiotics era.
Yinglu Wang +4 more
doaj +4 more sources
Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions [PDF]
Frontiers in Chemistry, 2021 Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs
Yeting Guo +15 more
doaj +4 more sources
Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold [PDF]
Biomolecules, 2021 Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of peptides widespread in nature, are unsurpassed in their structural and bio-functional diversity. DKPs, especially those containing proline, due to their unique features
Joanna Bojarska +11 more
doaj +4 more sources
Rational and combinatorial tailoring of bioactive cyclic dipeptides [PDF]
Frontiers in Microbiology, 2015 Modified cyclic dipeptides represent a diverse family of microbial secondary metabolites. They display a broad variety of biological and pharmacological activities and have long been recognized as privileged structures with the ability to bind to a wide ...
Tobias Wolfgang Giessen +2 more
doaj +7 more sources
Self-Assembly of Cyclic Dipeptides: Platforms for Functional Materials [PDF]
Protein and Peptide Letters, 2020 Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cyclic dipeptides have been studied in
Sigal Rencus-Lazar +2 more
exaly +4 more sources
Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides [PDF]
Molecules, 2021 Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide ...
Marco Scarel, Silvia Marchesan
doaj +2 more sources
Protein synthesis with conformationally constrained cyclic dipeptides. [PDF]
Bioorg Med Chem, 2020 We have synthesized several conformationally constrained dipeptide analogues as possible substrates for incorporation into proteins. These have included three cyclic dipeptides formed from Boc derivatives of 2,4-diaminobutyric acid, ornithine and lysine, having 5-, 6-, and 7-membered lactam rings, respectively.
Zhang C, Bai X, Dedkova LM, Hecht SM.
europepmc +4 more sources