Results 41 to 50 of about 4,865 (234)
Molecules, 2021 Pyrazines (1,4-diazirines) are an important group of natural products that have tremendous monetary value in the food and fragrance industries and can exhibit a wide range of biological effects including antineoplastic, antidiabetic and antibiotic ...
Hong-Bing Liu +6 more
doaj +1 more source
Stereocontrolled synthesis of unnatural cyclic dipeptides containing L-valine unit [PDF]
, 2005 Stereoselective synthesis of unusual nonproteinogenic dipeptides containing an L-valine unit and a cyclic unnatural alpha-amino acid, has been accomplished starting from the L-valine derived chiral synthon. The absolute configuration of new stereocenters
PORZI, GIANNI +3 more
core +1 more source
Cyclic dipeptides and their self-assembling properties [PDF]
, 2017 Over recent years, cyclic dipeptides, or 2,5-diketopiperazines, have found numerous applications in nanotechnology, such as biological drug delivery. Reasons for this include their ease of synthesis and numerous intrinsic properties. One such property is
Balangtaa, Jacob
core +3 more sources
Synthesis of leucine-based cyclic dipeptides
Proceedings of the National Academy of Sciences of Belarus, Chemical Series, 2020 3-benzyl-6-isobutylpiperazin-2,5-dione [cyclo(leucylphenylalanyl)], 3-isobutylpiperazin-2,5-dione [cyclo(-leucylglycyl)] and 3-(sec-butyl-)-6-isobutyl-piperazine-2,5-dione [cyclo(leucylisoleucine)] have been obtained by cyclization of methyl esters of tert-butyloxycarbonyl derivatives of dipeptides, for the synthesis of which both carbodiimide-promoted
V. A. Haidukevich +3 more
openaire +2 more sources
Cyclic dipeptides: Biological activities and self-assembled materials [PDF]
, 2020 Cyclic dipeptides (CDPs) are the smallest cyclic peptides containing 2,5-diketopiperazine rings. CDPs have advantages of structures and properties, including excellent hydrogen-bonding-forming ability (two hydrogen bonding acceptors and two hydrogen ...
Yan, Xuehai +5 more
core +1 more source
Direct Regioselective para‐Fluorination via I(I)/I(III) Catalysis
Angewandte Chemie, EarlyView.A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Christoph Roblick +5 more
wiley +2 more sources
Frontiers in Microbiology, 2022 The quorum-sensing (QS) cascade is responsible for the colonization and phenotypic behavior of the pathogenic organism and the regulation of diverse signal molecules.
Chintan Kapadia +8 more
doaj +1 more source
Crown-ether-modified cyclic dipeptides as supramolecular chiral catalysts [PDF]
, 2017 With the objective to develop supramolecular catalysts for useful chemical transformations, we report here a rapid and efficient solid-phase synthesis of novel cyclic dipeptides (crown-CDPs) with a diversity of L-DOPA derived crown ether substituents and
Voyer, Normand, Bérubé, Christopher
core +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Advanced Science, EarlyView.A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa +8 more
wiley +1 more source