Cyclic dipeptides and the human microbiome: Opportunities and challenges [PDF]
Bioorganic & Medicinal Chemistry, 2023 Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis.Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs), into their ...
Ogilvie, Charlene Elizabeth +1 more
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Untargeted metabolomics identifies a bacterial cyclic dipeptide that induces resistance to a rust fungus of beans [PDF]
Scientific ReportsGenistein and daidzein are isoflavonoid phytoalexins that increase rapidly during bean hypersensitive immunity to Pseudomonas savastanoi pv. phaseolicola. To understand how genistein and daidzein affect P. savastanoi pv.
Bret Cooper +2 more
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Enzymatical and microbial degradation of cyclic dipeptides (diketopiperazines). [PDF]
AMB Express, 2013 Diketopiperazines (DKPs) are cyclic dipeptides, representing an abundant class of biologically active natural compounds. Despite their widespread occurrence in nature, little is known about their degradation. In this study, the enzymatical and microbial cleavage of DKPs was investigated.
Perzborn M, Syldatk C, Rudat J.
europepmc +6 more sources
Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia Solanacearum [PDF]
Molecules, 2018 Ralstonia solanacearum is a causative agent of bacterial wilt in many important crops throughout the world. How to control bacterial wilt caused by R. solanacearum is a major problem in agriculture.
Shihao Song +7 more
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Visible Light‐Triggered Supramolecular Hydrogel Based on Cyclic Dipeptides Stabilized with Coulomb Interactions [PDF]
Macromolecular Materials and EngineeringAmphiphilic cyclic dipeptides are efficient supramolecular hydrogelators. They can be combined with molecular photoswitches to produce light‐responsive soft materials, which can be applied in controlled drug delivery. Here it is reported that an arginine‐
Angelika Seliwjorstow +4 more
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Frontiers in Cell and Developmental Biology, 2022 Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA ...
Tomo Shiota +13 more
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Active site remodelling of a cyclodipeptide synthase redefines substrate scope
Communications Chemistry, 2022 Cyclodipeptide synthases (CDPSs) generate a wide range of cyclic dipeptides using aminoacylated tRNAs as substrates, however the substrate selection mechanism is not yet known.
Emmajay Sutherland +2 more
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Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2delta by HRGC/MS using stable isotope dilution assay [PDF]
, 2022 S.2433-2444Lactic acid bacteria (LAB) play an important role as natural preservatives in fermented food and beverage systems, reducing the application of chemical additives.
Czerny, Michael +4 more
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Conformation for a beta-cyclodextrin monosubstituted with a cyclic dipeptide. [PDF]
Proceedings of the National Academy of Sciences, 1992 The structural characterization of a beta-cyclodextrin monosubstituted with the peptide cyclo(L-His-L-Leu) is reported. This work provides an x-ray example of a covalently bound group that folds in such a way that the terminal apolar side chain is retained in the hydrophobic interior of the cone-shaped cyclodextrin cavity.
Di Blasio B. +9 more
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Microbial Cell Factories, 2022 Background Cyclic dipeptides are an important class of natural products owing to their structural diversity and biological activities. In fungi, the cyclo-ring system is formed through the condensation of two α-amino acids via non-ribosomal peptide ...
Jianzhao Qi +9 more
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